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Table 3 Rates of ACP and IPD

From: Clinical and economic burden of pneumococcal disease in US adults aged 19–64 years with chronic or immunocompromising diseases: an observational database study

  ACP IPD
Variable Person-Years Rate per 100, 000 person-years Rate ratio (95% CI) Rate per 100, 000 person-years Rate ratio (95% CI)
 Overall 57,108,315.72 656.40 3.62
Age group
 19–49 35,360,219.65 438.26 1.77
 50–64 21,748,096.07 1011.08 6.63
Gender
 Female 27,290,491.17 658.00 3.77
 Male 29,817,824.55 654.93 3.48
Health plan type
 Fee-for-service 1,159,288.49 1395.17 10.44
 PPO/EPO 36,123,603.49 646.15 3.58
 HMO 6,943,639.48 620.81 3.25
 POS 4,046,790.82 705.74 3.56
HDHP/CDHP 6,592,500.88 566.14 2.76
 Unknown 2,242,492.56 726.11 4.50
Medical conditions
 Healthy 47,370,548.67 429.65 1.00 1.91 1.00
 Any at-risk or high-risk condition 9,737,767.05 1759.46 4.10 (4.07–4.12) 11.92 6.23 (5.72–6.80)
At-risk conditions
 Overall 7,119,125.33 1573.40 3.66 (3.64–3.69) 8.91 4.66 (4.21–5.15)
 Asthma 1,596,160.50 1783.09 4.15 (4.10–4.20) 7.71 4.03 (3.34–4.86)
 Chronic heart disease 1,432,517.29 2343.78 5.46 (5.39–5.52) 11.38 5.95 (5.04–7.03)
 Chronic lung disease 1,007,145.18 3530.77 8.22 (8.13–8.31) 20.16 10.54 (9.13–12.33)
 Chronic liver disease 607,949.48 1603.75 3.73 (3.66–3.81) 13.82 7.22 (5.78–9.03)
 Diabetes mellitus 3,656,304.75 1396.74 3.25 (3.22–3.28) 9.03 4.72 (4.16–5.35)
Number of at-risk conditions
 1 6,089,016.03 1251.81 2.91 (2.89–2.94) 6.98 3.65 (3.25–4.10)
  ≥ 2 1,030,109.30 3474.29 8.09 (8.00–8.18) 20.29 10.61 (9.13–12.33)
High-risk conditions
 Overall 2,618,641.72 2265.30 5.27 (5.22–5.32) 20.12 10.52 (9.45–11.72)
 Chronic renal disease 424,677.27 4045.19 9.42 (9.27–9.56) 41.44 21.67 (18.44–25.47)
 Cancer 1,825,298.26 2132.14 4.96 (4.91–5.02) 18.79 9.83 (8.68–11.13)
 Asplenia 40,691.59 3801.77 8.85 (8.42–9.30) 22.12 11.56 (6.00–22.30)
 HIV 108,115.60 1748.13 4.07 (3.89–4.26) 33.30 17.41 (12.48–24.29)
 Organ transplant 522,834.47 1611.03 3.75 (3.67–3.83) 8.03 4.20 (3.08–5.72)
Number of high-risk conditions
 1 2,325,408.37 2209.68 5.14 (5.09–5.19) 19.44 10.16 (9.08–11.38)
  ≥ 2 293,233.35 2706.38 6.30 (6.16–6.44) 25.58 13.37 (10.57–16.92)
  1. ACP all-cause pneumonia, HDHP/CDHP High Deductible/Consumer Driven Health Plan, CI confidence interval, HIV human immunodeficiency virus, HMO Health Maintenance Organization, IPD invasive pneumococcal disease, POS Point of Service, PPO/EPO Preferred/Exclusive Provider Organization