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Table 2 C-reactive protein and procalcitonin distributions by infection in 210 participants with a single target infection

From: C-reactive protein and procalcitonin to discriminate between tuberculosis, Pneumocystis jirovecii pneumonia, and bacterial pneumonia in HIV-infected inpatients meeting WHO criteria for seriously ill: a prospective cohort study

Biomarker concentration Total (N = 210) TB (n = 133) CAP (n = 61) PJP (n = 16) P-value c
Median CRP mg/L (IQR) 148 (96–224) 141 (97–203) 193 (108–264) 106.5 (79.5–131.5) TB vs.CAP: 0.02, CAP vs. PJP: 0.003
PJP vs. TB: 0.02
CRP ≥ 10 mg/La n (%) 206 (98) 131 (98.5) 60 (98.4) 15 (93.8) TB vs.CAP: 1.00d, CAP vs. PJP: 0.38d
PJP vs. TB: 0.29d
Median PCT μg/L (IQR) 0.8 (0.3–2.9) 0.7 (0.4–2.1) 2.0 (0.4–5.2) 0.2 (0.1–1.3) TB vs. CAP: 0.05, CAP vs. PJP: 0.01
PJP vs. TB: 0.05
PCT ≥ 0.02 μg/Lb: n (%) 209 (99.5) 132 (99) 61 (100) 16 (100)
PCT ≥ 0.1 μg/L: n (%) 199 (94.8) 128 (96.2) 58 (95.1) 13 (81.3) TB vs. CAP: 0.71d,, CAP vs. PJP: 0.10d
PJP vs. TB: 0.04d
PCT ≥ 0.25 μg/L: n (%) 170 (81) 112 (84) 50 (82) 8 (50) TB vs. CAP: 0.70, CAP vs. PJP: 0.008
PJP vs: TB: 0.001
PCT ≥ 0.5 μg/L: n (%) 137 (65.2) 87 (65.4) 43 (70.5) 7 (43.8) TB vs. CAP: 0.49, CAP vs. PJP: 0.05
PJP vs. TB: 0.11
PCT ≥ 2 μg/L: n (%) 69 (32.9) 36 (27.1) 30 (49.2) 3 (18.8) TB vs. CAP: 0.003, CAP vs. PJP: 0.05d
PJP vs. TB: 0.56d
PCT > 10 μg/L: n (%) 16 (8) 8 (6) 8 (13) 0 (0)
  1. Abbreviations: CRP C-reactive protein, PCT Procalcitonin, TB tuberculosis, CAP bacterial community-acquired pneumonia, PJP Pneumocystis jirovecii pneumonia
  2. aElevated concentration. bLower detectable limit for procalcitonin assay
  3. cHypothesis tests- Wilcoxon-Mann_Whitney test for non-normally distributed continuous data and Chi-square test for categorical data
  4. dFisher’s exact test where 1 or more cells < 5