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Table 1 Susceptibility to the antimicrobial agents, basic characterization and drug resistance gene of CNSE

From: Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the Eastern region of Heilongjiang Province, China

Isolate NO.

MIC(ug/mL)

bla genotype

MHT/mCIM

strain

Culture type

History of antibiotic use

Invasive procedure

outcome

MLST

AMP

AMS

TZP

CZO

CAZ

CRO

FEP

ATM

IMP

AMK

GEN

TOB

CIP

LEV

CNSE01

CNSE02

CNSE15

R

R

R

R

R

R

R

R

R

S

R

R

R

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE03

CNSE09

CNSE12

CNSE44

CNSE48

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Died

ST76

CNSE04

CNSE05

CNSE07

CNSE14

CNSE16

CNSE29

CNSE30

CNSE31

CNSE32

CNSE34

CNSE35

CNSE54

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE06

R

R

R

R

R

R

R

R

R

S

S

S

S

S

KPC-2, SHV

+/+

KP

Sputum

YES

YES

Died

ST323

CNSE08

CNSE11

R

R

R

R

R

R

R

R

R

S

R

R

R

R

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE10

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

NO

NO

Survived

ST76

CNSE17

R

R

R

R

R

R

R

R

R

S

R

R

S

S

KPC-2, SHV, CTX-M-15

+/−

KP

Sputum

YES

YES

Died

ST76

CNSE18

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, CTX-M-15

+/+

KP

Sputum

YES

YES

Died

ST76

CNSE19

R

R

R

R

R

R

R

R

R

S

S

I

R

R

KPC-2, NDM-5, CTX-M-14, TEM

−/+

EC

Blood

YES

YES

Survived

ND

CNSE20

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, NDM-5, SHV, CTX-M-177, TEM

+/+

KP

Sputum

YES

YES

Died

ST76

CNSE22

R

R

R

R

R

R

R

R

R

S

R

I

S

S

IMP-4, SHV, TEM

+/+

KP

Sputum

YES

YES

Died

ST896

CNSE23

R

R

R

R

R

R

R

R

R

S

R

R

R

R

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Blood

YES

YES

NR

ST76

CNSE24

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Blood

YES

YES

Survived

ST76

CNSE25

R

R

R

R

R

R

R

R

R

S

R

R

R

R

NDM-1, TEM, CTX-M-15

+/+

EC

Sputum

YES

YES

Survived

ND

CNSE26

R

R

R

R

R

R

R

S

R

S

S

S

S

S

IMP-4

+/+

KO

Sputum

YES

NO

Survived

ND

CNSE27

R

R

R

R

R

R

R

R

R

R

R

R

R

R

NDM-7, TEM, CTX-M-15

−/+

EC

Urine

YES

YES

Survived

ND

CNSE28

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Blood

YES

YES

Died

ST76

CNSE36

R

R

R

R

R

R

R

R

R

S

R

R

R

I

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Secretion

YES

YES

Survived

ST76

CNSE37

R

R

R

R

R

R

R

R

I

S

R

I

S

S

IMP-4, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Died

ST2964

CNSE38

R

R

R

R

R

R

R

R

R

S

R

R

S

S

NDM-1, SHV, CTX-M-15

−/+

ECL

Secretion

YES

YES

Survived

ND

CNSE39

R

R

R

R

R

R

R

R

R

S

S

S

S

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE40

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KO

Sputum

YES

YES

Survived

ND

CNSE41

R

R

R

R

R

R

R

R

S

S

R

R

R

S

−/+

SM

Secretion

NR

NR

NR

ND

CNSE42

R

R

R

R

R

R

R

R

I

R

R

R

S

S

IMP-4, TEM

+/+

ECL

Blood

YES

YES

Died

ND

CNSE43

R

R

R

R

R

R

R

R

R

S

R

R

R

R

KPC-2, SHV, TEM, DHA

+/+

ECL

Sputum

YES

YES

Died

ND

CNSE45

R

R

R

R

R

R

R

R

R

R

R

R

R

R

KPC-2, TEM

+/+

CF

pus

YES

YES

Survived

ND

CNSE46

R

R

R

R

R

R

R

R

R

S

R

I

R

R

NDM-1

IMP-4, SHV, TEM, CTX-M-15

+/+

ECL

Urine

YES

YES

Survived

ND

CNSE47

R

R

R

R

R

R

R

R

R

S

S

S

R

R

KPC-2, SHV

−/+

KP

Blood

YES

YES

Survived

ST11

CNSE49

R

R

R

R

R

R

R

R

R

S

R

R

R

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Blood

YES

YES

Survived

ST76

CNSE50

R

R

R

R

R

R

R

R

R

S

R

R

R

R

KPC-2, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE51

R

R

R

R

R

R

R

R

R

S

S

S

R

R

KPC-2, IMP-4, TEM, DHA

+/+

ECL

pus

YES

YES

Survived

ND

CNSE52

R

R

R

R

R

R

R

R

R

S

R

R

I

S

KPC-2, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

CNSE53

R

R

R

R

R

R

R

S

R

R

R

R

R

R

NDM-5, SHV

+/+

EC

Blood

YES

YES

Died

ND

CNSE55

R

R

R

R

R

R

R

R

R

S

R

R

R

S

KPC-2, SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

NR

ST76

CNSE56

R

R

R

R

R

R

R

R

R

S

R

R

R

S

SHV, TEM, CTX-M-15

+/+

KP

Sputum

YES

YES

Survived

ST76

  1. AMP ampicillin, AMS ampicillin-sulbactam, TZP piperacillin/tazobactam, CZO cefazolin, CAZ ceftazidime, CRO ceftriaxone, FEP cefepime, ATM aztreonam, IMP imipenem, GEN gentamicin, TOB tobramycin, AMK amikacin, CIP ciprofloxacin and LEV levofloxacin, KP Klebsiella pneumoniae, EC Enterobacter cloacae, EC Escherichia coli, KO Klebsiella oxytoca, CF Citrobacter freundii, SM Serratia marcescens, NR No Record, ND Not Determined