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Table 1 Characteristics of HIV-infected children on ART in the Maggsen Cohort Study.a–b Dakar, Senegal

From: Low prevalence of lipodystrophy in HIV-infected Senegalese children on long-term antiretroviral treatment: the ANRS 12279 MAGGSEN Pediatric Cohort Study

Characteristics 2–5 y 5–10 y 10–18 y Total P value
(N = 18) (N = 83) (N = 153) (N = 254)  
Study site          0.79
 Albert Royer Hospital 13 (72) 61 (73) 106 (69) 180 (71)  
 Roi Baudouin Hospital 5 (28) 22 (27) 47 (31) 74 (29)  
Girls 6 (33) 37 (45) 68 (44) 111 (44) 0.65
WHO classificationc          0.03
 Stage 1–2 8 (44) 14 (17) 29 (19) 51 (20)  
 Stage 3–4 10 (56) 69 (83) 124 (81) 203 (80)  
Moderate wastingd 0 14 (17) 49 (32) 63 (25) 0.002
WHZ/BMIZ, median (IQR) −0.7 (−1.6–0.2) −1.1 (−1.8 – −0.4) −1.6 (−2.2 – − 0.9) −1.4 (−2.0 – − 0.7) < 0.0001
HAZ, median (IQR) − 1.3 (−2.0 – − 1.0) −1.1 (− 1.7 – − 0.3) −1.2 (− 1.9 – − 0.5) −1.2 (− 1.8 – − 0.5) 0.37
Puberty onset 0 0 92 (60) 92 (36) < 0.0001
CD4 < 500 cells/mm3 2 (11) 7 (9) 38 (25) 47 (19) 0.01
Viral load < 40 copies/mL 7 (39) 57 (70) 108 (71) 172 (68) 0.02
Time on ART in month, median (IQR) 22 (11–30) 47 (31–61) 64 (34–100) 54 (32–84) < 0.0001
ARV drug classes
 2NRTI/NNRTI 15 (83) 65 (78) 72 (47) 152 (60)  
 2NRTI/PI 3 (17) 15 (18) 28 (18) 46 (18)  
 NRTI/NNRTI/nRTI 0 1 (1) 30 (20) 31 (12)  
 NRTI/nRTI/PI 0 2 (3) 22 (14) 24 (10)  
 NRTI/nRTI/PI/II 0 0 1 (1) 1 (0)  
  1. aAbbreviations: ART antiretroviral treatment, BMIZ body mass index for age z-score, HAZ height for age z-score, II integrase inhibitor, nRTI nucleotide reverse-transcriptase inhibitor, NRTI nucleoside reverse-transcriptase inhibitor, NNRTI non-nucleoside reverse-transcriptase inhibitor, IQR interquartile range, PI/r protease inhibitor boosted, RTV ritonavir, WHZ weight for height z-score
  2. bData are N (%) unless otherwise indicated
  3. cWHO symptoms classification: highest stage reached by the child before ART initiation
  4. dModerate wasting (moderate acute malnutrition) is defined for both weight-for-height z scores (WHZ) in children < 5 years or body mass index-for-age z score (BMIZ) in children ≥5 years as being ≥ − 3 and < −2 [20, 21]