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Table 1 Overview of results from serology and molecular diagnostic tests for Borrelia

From: Case report: persistently seronegative neuroborreliosis in an immunocompromised patient

 

26–08-2016 serum

31–08-2016 CSF

7–10-2016 CSF

4–11-2016 serum

19–01-2017 serum

Enzygnost IgM index

0.07 (negative)

  

0.64 (negative)

0.14 (negative)

Enzygnost IgG index

0.12 (negative)

  

0.08 (negative)

0.12 (negative)

C6 peptide index

0.393 (negative)

  

0.15 (negative)

0.24 (negative)

Liaison IgM index

< 0.10 (negative)

  

< 0.10 (negative)

< 0.10 (negative)

Liaison IgG

< 5.0 AU/ml (negative)

  

12.4 AU/ml (equivocal)

14.7 AU/ml (equivocal)

IgM blot (Mikrogen)

Negative

  

Negative

Negative

IgG blot (Mikrogen)

Negative (only p41 +)

  

Negative (only p41 +)

Negative (only p41 +)

Borrelia PCR

 

Negative

Positive, B. burgdorferi s.l.)

  

B. miyamotoi PCR

 

Negative

Negative

  

Pan-relapsing fever Borrelia PCR

 

Negative

Negative

  

Total IgA (g/l)

0.44 (reduced)

  

0.29 (reduced)

 

Total IgM (g/l)

< 0.18 (reduced)

  

< 0.18 (reduced)

 

Total IgG (g/l)

2.92 (reduced)

  

2.50 (reduced)