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Table 1 Overview of results from serology and molecular diagnostic tests for Borrelia

From: Case report: persistently seronegative neuroborreliosis in an immunocompromised patient

  26–08-2016 serum 31–08-2016 CSF 7–10-2016 CSF 4–11-2016 serum 19–01-2017 serum
Enzygnost IgM index 0.07 (negative)    0.64 (negative) 0.14 (negative)
Enzygnost IgG index 0.12 (negative)    0.08 (negative) 0.12 (negative)
C6 peptide index 0.393 (negative)    0.15 (negative) 0.24 (negative)
Liaison IgM index < 0.10 (negative)    < 0.10 (negative) < 0.10 (negative)
Liaison IgG < 5.0 AU/ml (negative)    12.4 AU/ml (equivocal) 14.7 AU/ml (equivocal)
IgM blot (Mikrogen) Negative    Negative Negative
IgG blot (Mikrogen) Negative (only p41 +)    Negative (only p41 +) Negative (only p41 +)
Borrelia PCR   Negative Positive, B. burgdorferi s.l.)   
B. miyamotoi PCR   Negative Negative   
Pan-relapsing fever Borrelia PCR   Negative Negative   
Total IgA (g/l) 0.44 (reduced)    0.29 (reduced)  
Total IgM (g/l) < 0.18 (reduced)    < 0.18 (reduced)  
Total IgG (g/l) 2.92 (reduced)    2.50 (reduced)