Table 1 Vaccination Response of children experiencing repetitive episodes of invasive pneumococcal disease
Patient | Underlying disease | Localization of Infection (serotypes) | Vaccine (s) given | Responder (R) / Non Responder (NR) |
|---|---|---|---|---|
1 | Complement C2 deficiency | Bacteremia × 2 (6B/34) | PPV23 | (NR) |
2 | Complement C2 deficiency | Bacteremia × 2 (12F/4) | PPV23 | (NR) |
3 | Syndrome, undefined | Bacteremia × 2 (7F/23F) | PPV23 multiple | (NR) |
4 | Shunt (Dandy-Walker syndrome) | Bacteremia × 2 (19F/19F) | PPV23 × 2 | (NR) |
5 | HSCT (MB Gaucher) | Bacteremia × 2 (18C/18C) | PPV23 | (NR) |
6 | No underlying condition found | Bacteremia × 2 (6B/6B) | PCV7 × 2, PPV23 | PCV7 (R), PPV23 (NR) |
7 | No underlying condition found | Bacteremia × 2 (6B/6B) | PCV7 × 3, PPV23 | PCV7 (Subnormal (Table 2), PPV23 (NR) |
8 | No underlying condition found | Bacteremia × 2 (6A/24F) | PCV13, PPV23 × 2 | PCV13 (R), PPV23 (NR) |
9 | Complement C2 deficiency | Bacteremia × 3 (6B/16F/14) | PCV/ × 2, PPV23 | PCV7 (R), PPV23 (NR) |
10 | Syndrome with malabsorption | Bacteremia × 3 (14/19A/19A) | PCV7, PPV23 | PCV7 (R), PPV23 (NR) |
11 | Toll-Like receptor signaling defect | Bacteremia × 5 (15C/7/7/38/NTpn) | PCV7 × 3 | PCV7 (Subnormal) (Table 2) |
12 | Leukemia | Bacteremia × 4 (18C/8/8/8) | PCV7 × 2, PPV23 | R |
13 | No underlying condition found | Meningitis × 2 (14/6B) | PCV7 × 3 | R |
14 | Univentricular heart | Bacteremia × 2 (33F/33F) | PPV23 | R |
15 | Complement C2 deficiency | Meningitis × 2 (4/14) | PPV23 x multiple | R |
16 | Klippel Trenaunay syndrome | Bacteremia × 3 (6A/24F/24F) | PPV23 | R |
17 | Asplenia congenitalis | Meningitis × 2 (6B/6A) | PPV23 | R |
18 | Complement C2 deficiency | Bacteremia × 2 (9 V/NTpn) | PCV7 × 2, PPV23 | R |
19 | No underlying condition found | Meningitis/bacteremia (19F/1) | PCV7 × 2 | R |
20 | Hepatic disease (Biliary atresia) | Bacteremia × 2 (9 N/23A) | PCV7 × 2 | R |
21 | CNS tumor, chemo treatment | Bacteremia × 2 (9 V/1) | PCV7 × 2 | R |
22 | HSCT (myelodysplasia) | Bacteremia × 2 (6B/6B) | PCV23 | R |
23 | Complement C2 deficiency | Bacteremia × 2 (6B/38) | PPV23 | R |
24 | Asplenia congenitalis | Meningitis × 2 (23F/15C) | PCV7 × 2, PPV23 | R |
25 | No underlying condition found | Bacteremia × 2 (19A/19A) | PCV13 | R |
26 | Hepatic disease (Biliary atresia) | Bacteremia × 2 (9 N/23A) | PCV7 | R |