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Table 3 Univariate and multivariate analysis of factors associated with 14-day mortality

From: Bloodstream infections caused by Klebsiella pneumoniae: prevalence of blaKPC, virulence factors and their impacts on clinical outcome

Characteristic Total Survivors Non-survivors P value Multivariate analysis
(n = 285) (n = 231) (n = 54) HR (95% CI) P value
Demographic data
 Age (years), mean (±SD) 56.8 ± 15.9 56.7 ± 16.4 57.2 ± 14.1 0.83   
 Male sex 199 (69.8) 159 (68.8) 40 (74.1) 0.45   
ICU hospitalization 69 (24.2) 48 (20.8) 21 (38.9) 0.005   
Nosocomial acquisition 206 (72.3) 158 (68.4) 48 (88.9) 0.002   
Underlying diseases
 Diabetes 63 (22.1) 52 (22.5) 11 (20.4) 0.73   
 Hematologic malignancy 31 (10.9) 23 (10.0) 8 (14.8) 0.30   
 Solid tumor 67 (23.5) 60 (26.0) 7 (13.0) 0.04   
 Solid organ transplantation 33 (11.6) 24 (10.4) 9 (16.7) 0.19   
 Heart disease 35 (12.3) 23 (10.0) 12 (22.2) 0.01   
 Chronic lung disease 28 (9.8) 25 (10.8) 3 (5.6) 0.24   
 Chronic kidney disease 62 (21.8) 38 (16.5) 24 (44.4) < 0.001   
Origin of BSI
 Respiratory tract 49 (17.2) 28 (12.1) 21 (38.9) < 0.001   
 Intraabdominal 36 (12.6) 26 (11.3) 10 (18.5) 0.15   
 Soft tissue 10 (3.5) 6 (2.6) 4 (7.4) 0.19   
 Intravenous catheter 10 (3.5) 9 (3.9) 1 (1.9) 0.75   
 Urinary tract 14 (4.9) 14 (6.1) 0 0.13   
 Biliary tract 52 (18.2) 51 (22.1) 1 (1.9) 0.001   
 Liver abscess 28 (9.8) 28 (12.1) 0 0.007   
 Unknown 72 (25.3) 60 (26.0) 12 (22.2) 0.57   
 Other(s) 13 (4.6) 8 (3.5) 5 (9.3) 0.14   
Clinical presentation
 APACHE II score, median (IQR) 18 (12–24) 15 (11–21) 26 (21–33.3) < 0.001   
 Pitt bacteremia score, median (IQR) 2 (1–6) 1 (0–3) 8 (4.75–10.5) < 0.001 1.24 (1.13–1.36) < 0.001
 Charlson comorbidity index, median (IQR) 2 (1–4) 2 (1–4) 3 (2–5) 0.02 1.24 (1.09–1.41) 0.001
 Septic shock 69 (24.2) 30 (13.0) 39 (72.2) < 0.001 2.61 (1.28–5.35) 0.009
 MODS 48 (16.8) 19 (8.2) 29 (53.7) < 0.001   
 Immunosuppression state 94 (33.0) 67 (29.0) 27 (50.0) 0.003   
Therapy
 Appropriate empiric therapy 189 (66.3) 163 (70.6) 26 (48.1) 0.002   
 Appropriate definitive therapy 230 (80.7) 194 (84.0) 36 (66.7) 0.004   
HM phenotype 69 (24.2) 61 (26.4) 8 (14.8) 0.08   
bla KPC 95 (33.3) 53 (22.9) 42 (77.8) < 0.001 2.20 (1.06–4.54) 0.034
rmpA 90 (31.6) 83 (35.9) 7 (13.0) 0.001   
  1. Data are presented as No. (%) unless otherwise specified; boldface, indicates statistical significance (p<0.05)
  2. Abbreviations: HM hypermucoviscous, BSIs bloodstream infection, CNS central nervous system, APACHE Acute Physiology and Chronic Health Evaluation, MODS multiple organ dysfunction syndrome, SD standard deviation, IQR interquartile range, CI confidence interval, HR hazard ratio