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Table 3 Univariable and multivariable analyses of factors associated with mortality for patients on ART at start of TB treatment

From: HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town

  PYRS Deaths Univariable Multivariable
Characteristic    HR (95% CI) P-value aHR (95% CI) P-value
Calendar year
 2009 11,479 1400 1   1  
 2010 11,646 1275 1.11 (0.81–1.51) 0.51 1.18 (0.85–1.63) 0.32
 2011 11,350 1135 1.06 (0.79–1.42) 0.71 1.17 (0.86–1.59) 0.32
 2012 11,095 1099 0.95 (0.72–1.26) 0.74 1.07 (0.80–1.44) 0.64
 2013 10,010 922 0.90 (0.68–1.20) 0.47 1.05 (0.77–1.42) 0.76
Age (per 10 years increase) 5581 634 1.27 (1.17–1.38) < 0.001 1.28 (1.17–1.40) < 0.001
Female gender 3232 329 1   1  
Male gender 2349 305 1.28 (1.09–1.50) 0.002 1.02 (0.86–1.20) 0.84
Re-treatment TB 2606 340 1   1  
New TB 2975 294 0.72 (0.61–0.83) < 0.001 0.71 (0.61–0.84) < 0.001
PTB 4411 494 1   1  
EPTB 1170 140 1.06 (0.88–1.28) 0.56 1.05 (0.86–1.27) 0.43
CD4 (per increase of 50 cells/mm3) 5389 603 1
0.87 (0.84–0.89)
< 0.001 1
0.87 (0.84–0.89)
P < 0.001
  1. PYRS person years, HR Hazard Ratio, aHR Adjusted Hazard Ratio, CI confidence interval, TB tuberculosis, PTB pulmonary tuberculosis, EPTB extra-pulmonary tuberculosis