Good concordance of HPV detection between cervico-vaginal self-samples and general practitioner-collected samples using the Cobas 4800 HPV DNA test

Table 2 Concordance and agreement between self-samples and GP-collected samples according to specific genotypes

	GP-collected samples						κ^a (95% CI)	Agreement (%) (95% CI)	Sensitivity (%) (95% CI)	Specificity (%) (95% CI)
	HPV 16/18^b positive		HPV16/18^b negative		Total
	n*	%	n*	%	n	%
Self-samples
HPV 16/18^b positive	14	6.6	6	2.8	20	9.4	0.73 (0.57–0.90)	95.7 (92.1–98.0)	82.4 (56.7–96.2%)	96.9 (93.5–98.8%)
HPV 16/18^b negative	3	1.4	190	89.2	193	90.6
Total	17	8.0	196	92.0	213	100
	HPV other^c positive		HPV other^c negative		Total
Self-samples	n*	%	n*	%	n
HPV other^c positive	30	14.1	15	7.0	45	21.1	0.64 (0.51–0.78)	88.7 (83.7–92.6)	76.9 (60.7–88.9%)	91.4 (86.2–95.1%)
HPV other^c negative	9	4.2	159	74.6	168	78.9
Total	39	18.3	174	81.7	213	100

n* = Women with co-infections with HPV16/18 and HPV of other types appear in both sub-analyses
^aCohen’s Kappa. “Poor” (κ ≤ 0.20), “Fair” (0.21 ≤ κ ≤ 0.40), “Moderate” (0.41 ≤ κ ≤ 0.60), “Good” (0.61 ≤ κ ≤ 0.80), or “Very good” (κ ≥ 0.81) (18)
^bHPV16/18: HPV16 and/or HPV18 including co-infections with HPV of other types (HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
^cHPV other: HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 including co-infections with HPV16/18. % = Row percentage

ISSN: 1471-2334