Skip to main content

Advertisement

Table 2 Concordance and agreement between self-samples and GP-collected samples according to specific genotypes

From: Good concordance of HPV detection between cervico-vaginal self-samples and general practitioner-collected samples using the Cobas 4800 HPV DNA test

  GP-collected samples κa (95% CI) Agreement (%) (95% CI) Sensitivity (%) (95% CI) Specificity (%) (95% CI)
  HPV 16/18b positive HPV16/18b negative Total  
n* % n* % n %
Self-samples
 HPV 16/18b positive 14 6.6 6 2.8 20 9.4 0.73 (0.57–0.90) 95.7 (92.1–98.0) 82.4 (56.7–96.2%) 96.9 (93.5–98.8%)
 HPV 16/18b negative 3 1.4 190 89.2 193 90.6     
 Total 17 8.0 196 92.0 213 100     
  HPV otherc positive HPV otherc negative Total  
Self-samples n* % n* % n      
 HPV otherc positive 30 14.1 15 7.0 45 21.1 0.64 (0.51–0.78) 88.7 (83.7–92.6) 76.9 (60.7–88.9%) 91.4 (86.2–95.1%)
 HPV otherc negative 9 4.2 159 74.6 168 78.9     
 Total 39 18.3 174 81.7 213 100     
  1. n* = Women with co-infections with HPV16/18 and HPV of other types appear in both sub-analyses
  2. aCohen’s Kappa. “Poor” (κ ≤ 0.20), “Fair” (0.21 ≤ κ ≤ 0.40), “Moderate” (0.41 ≤ κ ≤ 0.60), “Good” (0.61 ≤ κ ≤ 0.80), or “Very good” (κ ≥ 0.81) (18)
  3. bHPV16/18: HPV16 and/or HPV18 including co-infections with HPV of other types (HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
  4. cHPV other: HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 including co-infections with HPV16/18. % = Row percentage