Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults

BMC Infectious Diseases

Table 4 Treatment regimen and outcome for 6 patients who received intravenous immunoglobulin for extra-haematological manifestations associated with HPV-B19 infection

Predominant involvement	Patient 7	Patient 12	Patient 17	Patient 20	Patient 21	Patient 22
Predominant involvement	Chronic polyarthritis	Chronic poly-arthralgia	Membrano-proliferative GN + FSGS	Mononeuritis multiplex	Mononeuritis	Guillain-Barré syndrome
Treatment regimen
IVIg courses, n	1	1	20	20	1	1
IVIg first dose, g/kg	2	2	2	2	2	2
IVIg total dose, g/kg	2	2	36	37	2	2
Additional treatment	NSAIDs	NSAIDs	CS, ACEIs, ARBs	CS, AEDs	None	None
Outcome
Clinical response M1	Stable	Stable	Stable	Worse	Stable	Partial
Clinical response M2	Stable	Stable	Stable	Partial	Stable	Partial
Clinical response M6	Stable	Stable	Stable	Partial	Partial	Complete
HPV-B19 PCR negativity	Yes	Yes	No	No	No	No
Time to PCR negativity, months after diagnosis/1st course	11/06	21/12	–	–	–	–

Abbreviations: ACEIs angiotensin-converting enzyme inhibitors, AEDs antiepileptic drugs, ARBs angiotensin II receptor antagonists, CS corticosteroids, FSGS focal segmental glomerulosclerosis, GN glomerulonephritis, IVIg intravenous immunoglobulin, M month, NSAIDs non-steroidal anti-inflammatory drugs, PCR polymerase chain reaction

ISSN: 1471-2334