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Table 2 Mean (SE) FLU-PRO domain and total scores on Day 3 by baseline (Day 0) joint HAI/NAI status

From: Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model

FLU-PRO Total/Domain Score High HAI – High NAIa Low HAI – High NAIa Low HAI – Low NAIa Overall F value (P value)b Pairwise Comparisonc
N LS Mean (SE) N LS Mean (SE) N LS Mean (SE)
Daily Mean         
 Total Score 22 0.07 (0.04) 29 0.09 (0.04) 10 0.45 (0.06) 13.87 (<.0001) 1: 0.9599
2: < 0.0001
3: < 0.0001
 Nose 22 0.18 (0.10) 29 0.21 (0.08) 10 1.13 (0.14) 17.88 (<.0001) 1: 0.9713
2: < 0.0001
3: < 0.0001
 Throat 22 0.08 (0.05) 29 0.11 (0.04) 10 0.35 (0.07) 6.07 (0.0040) 1: 0.8095
2: 0.0055
3: 0.0148
 Eyes 22 0.05 (0.06) 29 0.05 (0.05) 10 0.33 (0.09) 4.14 (0.0209) 1: 0.9962
2: 0.0437
3: 0.0292
 Chest/Respiratory 22 0.05 (0.04) 29 0.08 (0.04) 10 0.26 (0.07) 3.69 (0.0310) 1: 0.8958
2: 0.0386
3: 0.0689
 Gastrointestinal 22 0.04 (0.03) 29 0.01 (0.02) 10 0.13 (0.04) 2.65 (0.0792) 1: 0.7754
2: 0.2510
3: 0.0794
 Body/Systemic 22 0.07 (0.06) 29 0.09 (0.05) 10 0.49 (0.08) 10.49 (0.0001) 1: 0.9666
2: 0.0004
3: 0.0004
  1. aHigh HAI - High NAI: HAI > = 1:40 and NAI > = 1:40; Low HAI – High NAI: HAI < 1:40 and NAI > = 1:40; Low HAI – Low NAI: HAI < 1:40 and NAI < 1:40
  2. bAn analysis of Variance (ANOVA) model
  3. cComparing mean FLU-PRO total/domain scores, 1: group 1 vs. group 2, 2: group 1 vs. group 3, 3: group 2 vs. group 3