Skip to main content

Table 2 Mean (SE) FLU-PRO domain and total scores on Day 3 by baseline (Day 0) joint HAI/NAI status

From: Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model

FLU-PRO Total/Domain Score

High HAI – High NAIa

Low HAI – High NAIa

Low HAI – Low NAIa

Overall F value (P value)b

Pairwise Comparisonc

N

LS Mean (SE)

N

LS Mean (SE)

N

LS Mean (SE)

Daily Mean

        

 Total Score

22

0.07 (0.04)

29

0.09 (0.04)

10

0.45 (0.06)

13.87 (<.0001)

1: 0.9599

2: < 0.0001

3: < 0.0001

 Nose

22

0.18 (0.10)

29

0.21 (0.08)

10

1.13 (0.14)

17.88 (<.0001)

1: 0.9713

2: < 0.0001

3: < 0.0001

 Throat

22

0.08 (0.05)

29

0.11 (0.04)

10

0.35 (0.07)

6.07 (0.0040)

1: 0.8095

2: 0.0055

3: 0.0148

 Eyes

22

0.05 (0.06)

29

0.05 (0.05)

10

0.33 (0.09)

4.14 (0.0209)

1: 0.9962

2: 0.0437

3: 0.0292

 Chest/Respiratory

22

0.05 (0.04)

29

0.08 (0.04)

10

0.26 (0.07)

3.69 (0.0310)

1: 0.8958

2: 0.0386

3: 0.0689

 Gastrointestinal

22

0.04 (0.03)

29

0.01 (0.02)

10

0.13 (0.04)

2.65 (0.0792)

1: 0.7754

2: 0.2510

3: 0.0794

 Body/Systemic

22

0.07 (0.06)

29

0.09 (0.05)

10

0.49 (0.08)

10.49 (0.0001)

1: 0.9666

2: 0.0004

3: 0.0004

  1. aHigh HAI - High NAI: HAI > = 1:40 and NAI > = 1:40; Low HAI – High NAI: HAI < 1:40 and NAI > = 1:40; Low HAI – Low NAI: HAI < 1:40 and NAI < 1:40
  2. bAn analysis of Variance (ANOVA) model
  3. cComparing mean FLU-PRO total/domain scores, 1: group 1 vs. group 2, 2: group 1 vs. group 3, 3: group 2 vs. group 3