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Table 1 Details of 38 cases of primary laryngeal Aspergillosis in immunocompetent patients reported over the period of 50 years, (English literature)

From: Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update

Case Reference Age/gender Geographical area Clinical presentation Initial diagnosis Associated factors Diagnosis method Fungal culture Aspergillus species involved treatment Follow up period and Outcome
1 Rao PB. 1969 48/M Pondicherry, S. India Hoarseness of voice NA None HE No NA No treatment 2 M-asymptomati
2 Ferlito A. et al. 1974 76/M Verona, Italy Hoarseness of voice NA None HE No NA No treatment 2 M- asymptomatic
3 Kheir SM et al. 1983 50/M Birmingham, UK Hoarseness of voice Malignancy COPD HE and Immunofluorescence studies No NA Topical nystatin powder 24 M- asymptomatic
4 Benson-Mitchell R et al. 1994 62/M London, UK Hoarseness of voice Malignancy None HE No NA No treatment 2 M- asymptomatic
5 Nong D, et al. 1997 30–40 4 M + 4F China Hoarseness of voice leading to aphonia, sore throat, Acute laryn giti, TB, malignancy None NA NA NA NA NA
6 Beust L, et al.. 1998 53/M Rennes, France Hoarseness of voice, respiratory distress None None HE No NA Laryngectomy 3 M- asymptomatic
7 Fairfax AJ, et al. 1999 75/M Staffor, UK Hoarseness of voice, aphonia None None HE and culture Yes A. fumigatus AMP-lozenges, 10 mg-4 W 1 M- Improved
8 Dean CM, et al. 2001 17/F Philadelphia, USA. Hoarseness of voice, vocal fatigue None NG NA NA NA NA NA
9 Ogawa Y, et al. 2002 73/M Tokyo, Japan Hoarseness of voice (History of Radiotherapy and DB) Malignancy None HE, surgery NO NA Oral ITCZ- 8 W and AMP-B gargle 2 M- No recurrence
10 Wittkopf J, et al. 2006 62/F Iowa, USA Fluctuating hoarseness True vocal fold cyst (? aspergilloma) Type II DB (well-controlled), hypertension, and GERD HE No NA Surgery NA- No recurrence
11 Ran Y, et al. 2008 36/F China Hoarseness of voice, vocal fatigue None Dexamethasone therapy for rhinitis and asthma HE, KOH, SEM and Culture Yes a A fumigatus Oral ITCZ (200 mg bd-4 W) 1 M- asymptomatic
12 Liu YC, et al. 2010 30/F
32/F
Hangzhou, China Hoarseness of voice True vocal cord cyst Vocal abuse, broad spectrum antibiotic therapy HE and Culture and FFPE-PCR Yes (no growth) a A. fumigatus Oral ITCZ (200 mg bd- 4 W) 1 M- asymptomatic
13 Ran Y, et al. 2011 30/F Chengdu, China Hoarseness of voice, vocal fatigue, expectoration, and occasional vomiting Laryngitis Vocal abuse, oral Antibiotics and dexamethasone use HE, KOH, SEM and Culture Yes a A fumigatus Oral ITCZ (200 mg bd- first 2 W, 200 mg qd next 2 W 1 M- asymptomatic
14 Sundarray C et al. 2011 NA Cuttack, India NA NA NA NA NA NA NA NA
15 Ran Y, et al. 2013 23/F China Hoarseness of voice, severe paroxysmal cough, tachypnea None Oral sex HE, SEM and Culture Yes a A. fumigatus Oral ITCZ (200 mg bd- 4 W 1 M- asymptomatic
16 Doloi PK, et al. 2014 35/F Assam, India Hoarseness of voice, cough None Keratosis of the larynx HE, KOH and Culture Yes A. fumigatus Oral ITCZ (100 mg qd- 3 W) 3 W- asymptomatic
17 Al-Ogaili Z, et al. 2014 77/F Australia Dysphagia and hoarseness Lymphoma Smoking,inhaled corticosteroids HE and Culture Yes Not speciated NA NA
18 Gangopadhyay M, et al. 2014 42/M West Bengal, India. Hoarsenes, fever, cough with expectoration Malignancy Smoking, vocal abuse HE, and Culture Yes A. niger Oral ITCZ 18 M- asymptomatic
19 Ravikumar et al. 2014 34/F
52/F
38/M
Tamil Nadu, India Hoarseness, cough, Dysphagia, vocal fatigue None NA GERD HE and KOH mount No NA Oral ITCZ (100 mg bd- 3 W) 3 W- asymptomatic
20 David et al. 2014 59/F Sydney, Australia Hoarseness of voice None Asthma- fluticasone therapy HE No NA Oral ITCZ NA: No recurrence
21 M Dutta, et al. 2015 45/F WB, India Hoarseness of voice Malignancy None HE, KOH and Culture Yes A. fumigatus Oral ITCZ (300 mg qd-3 W) 6 M- asymptomatic
22 JCR Villanueva, et al. 2015 28/F Philippines Hoarseness of voice Antibiotics and steroids None HE No No Oral VCZ (400 mg qd– 4 W) 1 M- asymptomatic
23 Arpita Saha, et al. 2015 28/F Odisha, India severe dysphonia None Asthma, long-term steroid inhaler, vocal abuse, broadspectrum antibiotics HE, and Culture Yes A. fumigatus VCZ (200 mg bd-8 days) 2 W- asymptomatic
24 Santosh Kumar Swain et al. 2016 35/M Orissa, India Hoarseness of voice Flute player Malignancy HE, KOH and Culture Yes A. fumigatus Oral ITCZ- 100 mg bd- 3 W 6 M- asymptomatic
25 Richard H. et al.. 2016 73/F USA persistent hoarseness None Inhaled and oral corticosteroids, and nebulized tobramycin HE NO NA Oral ITCZ-20 W 5 M- asymptomatic
26 Santosh Kumar et al. 2017 12/M India Hoarseness of voice None Asthma, inhaled corticosteroids, microlaryngeal surgery with stripping of the vocal cords HE, and Culture Yes A. fumigatus Oral ITCZ-50 mg bd- 3 W 3 W- asymptomatic
27 Soumen Chatterjee et.al. 2017 43/F India West Bengal Hoarseness of voice None None HE, KOH and Culture Yes A. fumigatus Oral ITC -100 mg bd- 8 W 1 M- asymptomatic
28 Present study 22/M Nepal hoarseness and frequent expectoration None None HE, KOH, Culture and FFPET-PCR assay Yes a A. fumigatus Oral ITCZ- 4 W 1 M- asymptomatic
No recurrence
  1. Legend: aSpecies identified via sequencing; HE Histopathological examination, COPD Chronic obstructive pulmonary disease, ITCZ Itraconazole, W Weeks, M Month, AMP-B Amphotericin B, DM Diabetes mellitus, GERD Gastroesophageal reflux disease, SEM scanning electron microscopy, VCZ Voriconazole