Skip to main content

Table 1 Patient demographics

From: Clinical course and significance of nontuberculous mycobacteria and its subtypes in cystic fibrosis

 

Patients with Slow-growing NTM #1 (N = 17)

Patients with Rapidly Growing NTM #2 (N = 8)

NTM-negative Patients #3 (N = 26)

P-values

 

N

N (%) or median (range)

N

N (%) or median (range)

N

N (%) or median (range)

Overall

1 vs 2

1 vs 3

2 vs 3

Age at first positive NTM culture, years

17

16.4 (6.4–41.6)

8

16.4 (3.1–21.5)

–

 

0.44a

0.44a

  

Gender

17

 

8

 

26

 

0.93

0.99

0.75

0.99

 Male

 

9 (53)

 

5 (63)

 

16 (62)

    

 Female

 

8 (47)

 

3 (37)

 

10 (38)

    

Age at CF diagnosis in months

11

1.2 (0.1–2.8)

5

4.5 (1.5–84.3)

22

2.4 (< 1–164.4)

0.046

0.013

0.053

0.52

Race

15

 

8

 

26

 

0.37

0.35

0.29

0.99

 Caucasian

 

15 (100)

 

7 (88)

 

23 (88)

    

 Black/Hispanic

 

–

 

1 (12)

 

3 (12)

    

CF diagnosis method b

12

 

5

 

24

     

 Newborn screening

 

8 (67)

 

1 (20)

 

10 (42)

0.24

0.18

0.75

0.23

Concomitant symptoms

 Meconium

 

3 (25)

 

–

 

5 (21)

0.51

0.53

0.99

0.31

 Chronic cough

 

1 (8)

 

–

 

–

0.49

0.99

0.40

–

 Recurrent respiratory infection

 

2 (17)

 

4 (80)

 

10 (42)

0.08

0.06

0.09

0.69

 Failure to thrive

 

3 (25)

 

4 (80)

 

8 (33)

0.25

0.16

0.48

0.41

 Frequent greasy or bulky stools

 

1 (8)

 

–

 

–

0.49

0.99

0.40

–

 Nasal polyps

 

–

 

–

 

1 (4)

0.92

–

0.99

0.99

 Other

 

1 (8)

 

2 (40)

 

4 (17)

0.41

0.23

0.63

0.61

p.F508del mutation status

17

 

8

 

26

 

0.44

0.46

0.25

0.84

 2 copies

 

10 (59)

 

4 (50)

 

17 (65)

    

 1 copy

 

7 (41)

 

3 (38)

 

6 (23)

    

 0 copies

 

–

 

1 (12)

 

3 (12)

    

Sweat-chloride level at diagnosis, mmol/L

13

101 (74–121)

5

105 (100–142)

22

109 (90–137)

0.026c

0.095

0.009

0.99

Pancreatic insufficiency

17

 

8

 

26

 

0.92

–

0.99

0.99

 No

 

–

 

–

 

1 (4)

    

 Yes

 

17 (100)

 

8 (100)

 

25 (96)

    

Diabetes diagnosis

17

 

8

 

26

 

0.67

0.99

0.67

0.57

 No

 

14 (82)

 

6 (75)

 

23 (88)

    

 Yes

 

3 (18)

 

2 (25)

 

3 (12)

    

FEV1 percent predicted

 Before NTM acquisition

17

92 (53–115)

7

84 (71–102)

–

–

0.80

0.80

–

–

 After NTM acquisition

17

91 (36–110)

8

80 (48–91)

–

–

0.23

0.23

–

–

FEF25–75% predicted

 Before NTM acquisition

17

79 (24–124)

7

64 (42–123)

–

–

0.80

0.80

–

–

 After NTM acquisition

17

68 (13–110)

8

51 (24–103)

–

–

0.59

0.59

–

–

Organism type

17

 

8

 

–

 

≤0.001

≤0.001

–

–

 MAC

 

15 (88)

 

–

 

–

    

 M. fortuitum

 

–

 

2 (25)

 

–

    

 M. abscessus

 

–

 

6 (75)

 

–

    

 M. gordonae

 

2 (12)

 

–

 

–

    

Number of positive NTM cultures

17

1 (1–3)

8

2.5 (1–7)

–

–

0.18

0.18

–

–

  1. aSignificant difference between patients infected with rapidly growing bacteria and NTM-negative patients (P = 0.013)
  2. bMore than one method of diagnosis may have been used
  3. cSignificant difference between patients infected with slow-growing bacteria and NTM-negative patients (P = 0.009)
Back to article page

BMC Infectious Diseases

ISSN: 1471-2334

Contact us