Table 2 Parameters during the follow-up in the TDF-reducing therapy group (n = 364). Dual therapy (DT) Alanine transaminase (ALT) Aspartate transaminase (AST) High-density lipoprotein (HDL) Low-density lipoprotein (HDL) Creatinine clearance (CCr) platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte ratio (NLR)
Parameters | 12Â months before Mean (SD) | 6Â months before Mean (SD) | Swicht to DT Mean (SD) | 6Â months after switch Mean (SD) | 12Â months after switch Mean (SD) | From 12Â months before to switcha Coef. (CI 95%) | p-value | From switch to 12Â months aftera Coef. (CI 95%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
CD4 cell count, cell/mm3 | 611.1 (302.8) | 630.5 (300.5) | 631.6 (295.6) | 659.3 (295.9) | 699.2 (296.3) | 1.9 (0.3,3.5) | 0.023 | 6.8 (4.9,8.8) | < 0.001 |
CD8 cell count, cell/mm3 | 900.1 (423.6) | 910.2 (439.7) | 872.3 (438.6) | 928.4 (475.8) | 919.2 (474.2) | −1.8 (− 4.9,1.4) | 0.272 | 4.2 (1.2, 7.6) | 0.007 |
ALT (U/l) | 40.8 (46.8) | 38.4 (33.9) | 37.2 (30.4) | 38.4 (44.6) | 36.6 (35.6) | −0.3 (− 0.7,0.0) | 0.045 | − 0.0 (− 0.1,0.4) | 0.890 |
AST (U/l) | 33.6 (37.4) | 30.3 (22.8) | 30.3 (24.3) | 29 (29.4) | 30.2 (26.6) | −0.3 (− 0.6–0.0) | 0.028 | −0.0 (− 0.3,0.2) | 0.760 |
Total Cholesterol (mg/dl) | 184.9 (40.6) | 186.9 (40.6) | 186 (41.4) | 208.4 (45.9) | 199.7 (45.5) | 0.1 (−0.2,0.4) | 0.601 | 1.5 (1.1,1.9) | < 0.001 |
HDL Cholesterol (mg/dl) | 44.7 (14.8) | 45.9 (16.4) | 46 (15.9) | 49.6 (15.4) | 48.9 (15.9) | 0.2 (0.0,0.3) | 0.009 | 0.3 (0.2,0.5) | < 0.001 |
LDL Cholesterol (mg/dl) | 111.9 (35) | 113.1 (34.5) | 114.3 (34) | 125.1 (37.2) | 120 (38.2) | −0.1 (−0.2, 0.5) | 0.534 | 0.7 (0.2, 1.1) | 0.005 |
Triglycerides (mg/dl) | 157.1 (90.9) | 160.5 (85.1) | 155.7 (105.2) | 174.3 (125.3) | 176.3 (141.2) | −0.2 (−1.2,0.7) | 0.629 | 1.3 (0.3,2.3) | 0.009 |
CCr (ml/min) | 92.1 (25.2) | 91.1 (28.5) | 88.6 (30.2) | 93.2 (28.6) | 95.8 (29.7) | −0.4 (−0.5, − 0.2) | < 0.001 | 0.5 (0.3,0.6) | < 0.001 |
Lymphocyte, 103/μL | 2087 (789) | 2100 (767) | 2062 (791) | 2202 (868) | 2236 (867) | −3.3 (−8.0, 3.3) | 0.259 | 16.9 (11.2,22.6) | < 0.001 |
Neutrophils, 103/μL | 4230 (5825) | 3435 (1386) | 3422 (1344) | 3444 (1463) | 3560 (1610) | −65.4 (− 127.4–3.4) | 0.039 | 20.3 (− 1.8, 42.4) | 0.072 |
Platelets, 103/μL | 216,359 (76022) | 216,525 (73144) | 218,494 (72903) | 214,413 (69168) | 214,286 (69895) | −10.9 (− 394.4, 372.96) | 0.955 | − 420.4 (− 810.2, − 30.5) | 0.035 |
NLR | 1.9 (0.9) | 1.9 (0.9) | 2 (1.1) | 1.9 (1.2) | 1.9 (0.9) | 0.1 (0.0,0.2) | 0.067 | 0.0 (−0.0, 0.0) | 0.355 |
PLR | 114.2 (51.5) | 113.4 (51.6) | 118.7 (59.5) | 109.4 (52.8) | 105.0 (46.0) | 0.3 (−0.1, 0.8) | 0.110 | −1.2 (−1.6,-0.7) | < 0.001 |
CD4/CD8 | 0.79 (0.48) | 0.8 (0.5) | 0.84 (0.47) | 0.81 (0.42) | 0.88 (0.43) | 0.004 (0.001,0.008) | 0.008 | 0.003 (0.001,0.005) | 0.002 |