Table 1 Characteristics of 23 published studies included for meta-analysis and the primary results of Xpert MTB/RIF test
First author | Year | Country | Patients enrolled | Mean age (years)a | HIV-infection prevalence (%) | Specimen types | Reference standard | Results | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
TP | FP | FN | TN | ||||||||
Causse | 2011 | Spain | 34 | 45(5–83) | NR | Pleural fluid | Culture | 4 | 0 | 0 | 30 |
Friedrich | 2011 | South Africa | 25 | NR | NR | Pleural fluid | Culture | 5 | 0 | 15 | 5 |
Malbruny | 2011 | France | 12 | 52 | 4.3% | Pleural fluid | Culture | 0 | 0 | 2 | 10 |
Moure | 2012 | Spain | 31 | NR | NR | Pleural fluid | Culture | 7 | 0 | 19 | 5 |
Tortoli | 2012 | Italy | 330 | NR | NR | Pleural fluid | Culture | 5 | 3 | 10 | 312 |
Christopher | 2013 | India | 91 | 46(33–57) | NR | Pleural fluid | Culture and biopsy | 4 | 0 | 26 | 61 |
Porcel | 2013 | Spain | 67 | 50 | 0% | Pleural fluid | Culture and biopsy | 5 | 0 | 28 | 34 |
Zmak | 2013 | Croatia | 42 | NR | NR | Pleural fluid | Culture | 0 | 0 | 1 | 41 |
Javed | 2014 | Pakistan | 25 | NR | NR | Pleural fluid | Biopsy | 2 | 0 | 12 | 11 |
Lusiba | 2014 | Uganda | 116 | 34 ± 13 | 44.8% | Pleural fluid | Culture and biopsy | 25 | 1 | 62 | 28 |
Meldau | 2014 | South Africa | 88 | 51 | 10.2% | Pleural fluid | Culture and biopsy | 9 | 1 | 31 | 47 |
Scott | 2014 | South Africa | 528 | 39 | NR | Pleural fluid | Culture | 227 | 3 | 255 | 43 |
Sharma SK | 2014 | India | 364 | NR | NR | Pleural fluid | Culture | 37 | 8 | 54 | 265 |
Theron | 2014 | South Africa | 76 | 55(38–65) | 17% | Pleural fluid | Culture | 5 | 6 | 11 | 54 |
Trajman | 2014 | Brazil | 59 | 50 | 5% | Pleural fluid | Culture and biopsy | 1 | 0 | 32 | 26 |
Coleman | 2015 | Malawi | 50 | 32 | 100% | Pleural fluid | Culture | 9 | 0 | 4 | 18 |
Liu | 2015 | China | 126 | 38.6 ± 13.2 | 4.0% | Pleural fluid | Culture | 24 | 1 | 31 | 70 |
Rufai | 2015 | India | 162 | 41.6 ± 19 | 0% | Pleural fluid | Culture | 23 | 0 | 19 | 119 |
Wang | 2015 | China | 125 | 43 | NR | Pleural fluid | Culture | 13 | 47 | 0 | 65 |
Che | 2017 | China | 78 | 44 (18–83) | 1.3% | Pleural fluid | Culture and biopsy | 12 | 0 | 48 | 18 |
Li | 2018 | China | 70 | 42 ± 20 | 0% | Pleural fluid | Culture and biopsy | 6 | 0 | 39 | 25 |
Sharma S | 2018 | India | 37 | 39 | 0% | Pleural fluid | Culture and biopsy | 5 | 0 | 2 | 30 |
Christopher | 2018 | India | 130 | 50.9 ± 14.1 | 0% | Pleural fluid | Biopsy | 9 | 0 | 56 | 65 |