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Table 1 Analyses of risk factors for the incidence of liver failure in all patients (n = 84)

From: Co-infection with hepatitis B virus among tuberculosis patients is associated with poor outcomes during anti-tuberculosis treatment

Factors Univariate analysis Multivariate analysis
OR 95%CI P-value OR 95%CI P-value
Age > 50 1.913 0.79, 4.64 0.151 1.603
1.930
0.55, 4.67
0.75, 4.92
0.387
0.169
Male 1.774 0.61, 5.18 0.294 0.581
0.848
0.16, 2.16
0.20, 2.97
0.417
0.796
Alcohol intake > 40 g/d 1.081 0.28, 4.16 0.909
INH + RFP 0.469 0.16, 1.36 0.165 0.775
0.538
0.21, 2.86
0.18, 1.64
0.702
0.275
Latency < 1 month 0.667 0.21, 2.11 0.490
Hepatocellular DILI 0.689 0.27, 1.76 0.435
Cirrhosis 13.347 4.05, 43.98 0.000 11.484 3.16, 41.73 0.000
HBsAg-positive 3.284 1.26, 8.59 0.015 2.658
3.232
1.19, 5.58
1.08, 9.64
0.041
0.035
  1. In addition to male gender, variables with P < 0.200 in the univariate analysis were included in the multivariate analysis. Adjusted statistical data were shown in italic font if the variable of cirrhosis was discarded due to its correlation with chronic HBV infection
  2. Abbreviations: INH isoniazid, RFP rifampin, DILI drug-induced liver injury, HBsAg hepatitis B virus surface antigen