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Table 3 Genetic variation associated with DENV disease. We include in this table all variants studied by two or more research groups and variants found to have a significant association by one research group

From: Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis

Gene Genetic Variation Entrez Gene ID [31] Major Allele Minor Allele Number of Cases Number in Comparison Group Country Key Results Meta-Analyzed
BAK1 rs5745568 578 G T 509 DHF/DSS 409 DF Thailand 1.32 (1.09–1.60) odds of severe disease associated with G allele [67] No
CCR5 rs333 1234 Δ32 deletion 56 DF 91 controls Australia No significant association with disease [68] Yes
88 DHF/DSS 335 controls Brazil No significant association with disease [69]
CD209/ DCSIGN rs480803 30,835 A G 509 DHF/DSS 409 DF Thailand No significant association with disease [67] Yes
A G 88 DHF/DSS 335 controls Brazil No significant association with disease [69]
A G 112 symptomatic 104 controls India No significant association with disease [70]
A G 103 symptomatic 145 asymptomatic infections Mexico No significant association with disease [71]
A G 156 DF and 12 DHF 72 controls Brazil No significant association with disease [72]
A G 606 symptomatic 696 controls Thailand 5.84 (2.77–12.31) odds of DHF compared to DF and 0.204 (P = 2.0 × 10− 6) odds of symptomatic infection compared to controls [73]
A G 286 symptomatic 236 asymptomatic infections Brazil No significant association with disease [74]
A G 176 DF and 135 DH0046 120 controls Taiwan 2.36 (1.12–4.97) odds of symptomatic infection compared to controls, 3.68 (1.67–8.09) odds of DHF compared to controls, and 2.46 (1.32–4.59) odds of DHF compared to DF [75]
CFH rs3753394 3075 C T 187 DHF 121 DF Thailand No significant association with disease [76] Noa
    C T 87 DHF 34 DF Brazil 2.53 (1.38–4.69) odds of severe disease compared to mild disease under dominant model [77]  
CLEC5A rs1285933 23,601 T C 88 DHF/DSS 335 controls Brazil 2.25 (1.07–4.87) odds of severe disease for TT compared to CC genotype [69] No
CXCL8/ IL8 rs4973 3576 T A 45 DHF 108 controls India 0.43 (0.20–0.93) odds of severe disease [78] No
DDX58 rs3205166 23,586 T G 120 DENV positive 109 controls India 0.66 odds of disease associated with G allele for rs3205166 [79] No
rs11795343
rs669260
FCγRII-α rs1801274 2212 A (H amino acid) G (R amino acid) 103 symptomatic 145 asymptomatic infections Mexico 0.51 (0.26–0.98) odds of symptomatic infection and 0.45 (0.21–0.96) odds of severe disease compared to controls [71] Yes
T (H) C (R) 89 DF and 33 DHF 107 controls India No significant association with disease [80]
T (H) C (R) 68 DF, 29 DHF/DSS 42 asymptomatic infections Cuba 10.56 (2.33–54.64) odds of DHF compared to asymptomatic disease for under dominant model [81]
T (H) C (R) 302 DHF 238 controls Vietnam No significant association with disease [82]
T (H) C (R) 40 DF, 30 DHF/DSS 40 asymptomatic infections Pakistan 3.21 (1.29–7.97) odds of symptomatic disease, 2.82 (1.00–7.97) odds of DF, and 3.90 (1.13–13.07) odds of DHF/DSS over asymptomatic infection [83]
HPA HPA 1a/1a Not available 1a antigen 1b antigen 75 DHF 90 DF India 1.93 odds (p = 0.006) of severe disease [84] No
HPA 2a/2b 2a antigen 2b antigen 75 DHF 90 DF India 2.8 odds (p = 0.007) of severe disease [84] No
IFN-γ rs2430561 3458 A T 80 symptomatic 100 DEN-negative febrile cases and 99 healthy controls Brazil 2.23 (p = 0.0255) odds compared to DEN-negative and 2.37 (p = 0.0165) odds compared to controls [85] Yes
A T 25 DHF 41 DF Venezuela No significant association with disease [86]
A T 43 DHF 99 controls Cuba No significant association with disease [87]
IL-1B rs16944 3553 A G 45 DHF 108 controls India No significant association with disease [78] Yes
C T 118 symptomatic 80 controls Brazil No significant association with disease [88]
rs1143627 C T 367 secondary DHF and 74 secondary DSS 313 secondary DF Thailand 3.49 (1.36–8.95) odds of DSS compared to DHF and 2.81 (1.12–7.06) odds of DSS compared to DF under dominant models [89] No
IL-1RA 86 base pair tandem repeat 3557 4 repeats 2 repeats 367 secondary DHF and 74 secondary DSS 313 secondary DF Thailand 1.86 (1.05–3.26) odds of DSS compared to DHF and 1.86 (1.05–3.27) odds of DSS compared to DF for the 2/4 genotype [89] Noa
1 repeat 2–4 repeats 280 DHF 229 controls Vietnam No significant association between IL-1RA repeats and DHF [82]
IL-6 rs1800795 3569 G C 25 DHF 41 DF Venezuela No significant association with disease [86] Yes
G C 43 DHF 99 controls Cuba No significant association with disease [87]
G C 118 symptomatic 80 controls Brazil No significant association with disease [88]
G C 200 DF 309 controls Brazil 0.62 (0.42–0.91) odds of disease among heterozygotes compared to homozygote wild-type [90]
IL-10 rs1800871 3586 C T 88 DSS 335 controls Brazil No significant association with disease [69] Yes
A G 45 DHF 108 controls India No significant association with disease [78]
C T 25 DHF 41 DF Venezuela No significant association with disease [86]
C T 43 DHF 99 controls Cuba No significant association with disease [87]
C T 200 DF 309 controls Brazil No significant association with disease [90]
T C 86 DF, 182 DHF, 14 DSS 120 controls Malaysia No significant association with disease [91]
C T 107 DHF 62 controls Sri Lanka No significant association with disease [92]
rs1800872 C A 25 DHF 41 DF Venezuela No significant association with disease [86] Yes
C A 43 DHF 99 controls Cuba No significant association with disease [87]
C A 200 DF 309 controls Brazil No significant association with disease [90]
A C 86 DF, 182 DHF, 14 DSS 120 controls Malaysia No significant association with disease [91]
A C 107 DHF 62 controls Sri Lanka No significant association with disease [92]
rs1800896 A G 25 DHF 41 DF Venezuela No significant association with disease [86] Yes
A G 43 DHF 99 controls Cuba No significant association with disease [87]
A G 200 DF 309 controls Brazil No significant association with disease [90]
A G 86 DF, 182 DHF, 14 DSS 120 controls Malaysia No significant association with disease [91]
A G 107 DHF 62 controls Sri Lanka No significant association with disease [92]
JAK1 rs11208534 3716 T C 50 DHF 236 DF Brazil 4.20 (1.7–10.4) odds of severe disease [74] No
rs2780831 G A 50 DHF 236 DF Brazil 2.1 (1.1–4.1) odds of severe disease [74] No
rs310196 T G 50 DHF 236 DF Brazil 0.4 (0.2–0.7) odds of severe disease [74] No
MBL2 Exon 1 4153 A O 110 symptomatic 150 controls Brazil No significant association with disease [93] Yes
A O 57 DHF 104 DF Brazil 7.24 (1.38–38.02) odds of DHF among OO genotype compared to AA genotype [94]
MICB rs3132468 4277 T C 76 DSS 409 DF, 432 DHF Thailand 1.58 (1.02–2.40) odds of DSS compared to non-DSS [95] Yes
T C 2008 DSS 2018 controls Vietnam 1.34 (1.23–1.46) odds of DSS per allele [96]
T C 3961 cases 1068 controls Vietnam 1.42 (1.20–1.64) odds of DSS per allele [97]
PLCE1 rs3740360 51,196 A C 2008 DSS 2018 controls Vietnam 0.80 (0.75–0.86) odds per allele of DSS [96] Yes
A C 3961 cases 1068 controls Vietnam 0.77 (0.59–0.99) odds per allele of DSS [97]
rs3765524 C T 76 DSS 409 DF, 432 DHF Thailand 1.49 (1.00–2.26) odds of DSS compared to non-DSS [95] Yes
C T 2008 DSS 2018 controls Vietnam 0.80 (0.75–0.86) odds per allele of DSS [96]
RXRA rs12339163 6256 G A 60 DHF 137 asymptomatic infections and controls Cuba 0.36 (0.17–0.77) odds of severe disease [98] No
rs3118593 A C 60 DHF 137 asymptomatic infections and controls Cuba 0.44 (0.25–0.77) odds of severe disease [98]
rs4262378 G A 60 DHF 137 asymptomatic infections and controls Cuba 0.41 (0.24–0.72) odds of severe disease [98]
rs4424343 A G 60 DHF 137 asymptomatic infections and controls Cuba 0.43 [0.24–0.76] odds of severe disease [98]
rs62576287 C A 60 DHF 137 asymptomatic infections and controls Cuba 0.10 (0.01–0.83) odds of severe disease [98]
TAP1 amino acid 333 6890 Ile Val 90 DF, 75 DHF, 32 DSS 100 controls India 2.58 (p = 0.007) odds of DHF among heterozygotes compared to DF [84] Yes
Ile Val 107 DHF 62 controls Sri Lanka No significant association with disease [92]
TAP2 amino acid 379 6891 Val Ile 107 DHF 62 controls Sri Lanka No significant association with disease [92] Yes
Val Ile 90 DF, 75 DHF, 32 DSS 100 controls India 2.11 (p = 0.001) odds of DHF among heterozygotes [99]
TGFβ1 rs1800471 7040 G C 25 DHF 41 DF Venezuela No significant association with disease [86]  
G C 200 DF 309 controls Brazil No significant association with disease [90]
rs1982073 T C 25 DHF 41 DF Venezuela No significant association with disease [86] Yes
T C 43 DHF 99 controls Cuba No significant association with disease [87]
T C 200 DF 309 controls Brazil No significant association with disease [90]
TIRAP rs8177374 114,609 C T 33 DHF 109 controls India 2.64 (1.17–5.99) odds of severe disease among heterozygotes [100] No
TLR3 rs3775291 7098 C T 33 DHF 87 DF India 0.39 (0.16–0.88) odds of severe disease associated with T allele [100] No
TNF-α rs361525 7124 G A 86 DF, 182 DHF, 14 DSS 120 controls Malaysia 4.92 (1.10–21.90) odds of DHF compared to control group for heterozygotes [91] Yes
G A 41 DF, 32 DHF 169 controls Mexico 0.19 (0.02–0.78) odds of disease with A allele [101]
rs1800629 G A 80 symptomatic 100 DEN-negative febrile cases and 99 healthy controls Brazil No significant association with disease [85] Yes
G A 25 DHF 41 DF Venezuela 2.5 (1.47–4.13) odds of severe disease [86]
G A 43 DHF 99 controls Cuba 3.51 (1.77–7.00) odds of severe disease [87]
G A 200 DF 309 controls Brazil No significant association with disease [90]
G A 86 DF, 182 DHF, 14 DSS 120 controls Malaysia 0.43 (0.22–0.84) odds of DHF compared to control for heterozygotes [91]
G A 107 DHF 62 controls Sri Lanka 2.53 (1.10–5.83) odds of disease for GG genotype [92]
G A 85 DF, 29 DHF 110 controls India No significant association with disease [102]
G A 19 DF, 82 DHF 106 controls Thailand No significant association with disease [103]
G A 85 DF, 45 DHF 163 controls Mexico No significant association with disease [101]
TLR4 amino acids 299 and 399 7099 Asp299, Thr399 Gly299, Ile399 201 DHF 179 controls Indonesia No significant association with disease [104] Yes
Asp299, Thr399 Gly299, Ile399 63 DF, 57 DHF/DSS 200 controls India 2.00 (1.17–3.43) odds associated with Gly299 for DF versus controls, and 2.38 (1.16–4.85) associated with Ile399 for DF versus controls [105]
VDR rs731236 7421 T C 302 DHF 238 controls Vietnam Associated with more severe disease (p = 0.033) [82] Yes
T C 83 DF, 29 DHF 105 controls India No significant association with disease [106]
  1. a genotype data not available for meta-analysis