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Table 2 Genetic variation significantly associated with West Nile virus disease. We include in this table all variants studied by two or more research groups and variants found to have a significant association by one research group

From: Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis

Gene Genetic variant Entrez Gene ID [31] Major Allele Minor Allele Number of Cases Number in Comparison Group Country Key Results Included in meta-analysis
ANPEP rs25651 290 T C 560 severe 950 non-severe infections US & Canada 0.69 odds of severe disease [59] Noa
G A 39 severe 61 controls Israel No significant association with disease [60]
CACNA1H rs113802594 8912 A G 1330 severe 919 non-severe infections US & Canada 8.58 odds of encephalitis [61] No
CCR5 CCR5 Δ32 1234 Δ32 deletion 560 severe 950 non-Severe infections US & Canada No significant association with disease [59] Yes
Δ32 deletion 39 severe 61 controls Israel No significant association with disease [60]
Δ32 deletion 422 symptomatic 331 asymptomatic infections US & Canada No significant association with disease [62]
Δ32 deletion 634 infections 422 controls US No significant association with disease, but significant association with more severe disease (p = 0.0016) [46]
Δ32 deletion 395 symptomatic (two cohorts of 247 and 148) 1318 controls US Significantly associated with disease in two cohorts (OR = 4.4 [1.6–11.8] and OR = 9.1 [3.4–24.8]), and fatal outcomes in one cohort with OR = 13.2 [1.9–89.9] [63]
HERC5 rs148556308 51,191 A G 1330 severe 919 non-severe infections US & Canada Significantly associated with severe disease (p-value = 6.5 × 10− 10) [61] No
IRF3 rs2304207 3661 G C 422 severe 331 asymptomatic infections US 0.52 odds of symptomatic infection under dominant model [62] Noa
G C 39 severe 61 controls Israel No significant association with disease [60]
MIF rs5844572 4282 5 or 6 CATT repeats 7 CATT repeats 518 severe 514 non-severe US & Canada 1.73 odds of encephalitis among patients with high-expression allele as compared to all other types of WNV disease [64] No
MX1 rs7280422 4599 C G 39 severe 61 controls Israel 4.05 odds of infection associated with variant allele [60] Noa
C G 422 severe 331 asymptomatic infections US 0.25 odds of symptomatic infection under a recessive model [62]
OASL rs3213545 8638 C T 422 severe 331 asymptomatic infections US No significant association with disease [62] Yes
C T 39 severe 61 controls Israel 1.85 (1.03–3.3) odds of infection [60]
C T 33 symptomatic 60 controls US Significantly associated with disease (P < 0.004) [65]
OAS1 rs10774671 4938 A G 422 severe 331 asymptomatic infections US No significant association with disease [62] Yes
A G 39 severe 61 controls Israel No significant association with disease [60]
A G 501 seropositive 552 controls US 1.6 [95% CI 1.2–2.0] odds of seroconversion [66]
OAS1 rs34137742 4938 C T 422 severe 331 asymptomatic infections US 9.79 [95% CI 3.60–26.61] odds of encephalitis and paralysis [62] Yes
C T 39 severe 61 controls Israel No significant association with disease [60]
RFC1 rs2066786 5981 T C 560 severe 950 non-severe infections US & Canada 0.68 odds of severe disease associated with minor allele [59] Noa
G A 39 severe 61 controls Israel 2.8 odds under dominant model [60]
SCN1A rs2298771 6323 C T 560 severe 950 non-severe infections US & Canada 1.47 odds of severe disease associated with minor allele [59] Noa
A G 39 severe 61 controls Israel No significant association with disease [60]
TFCP2L1 rs11122852 29,842 A T 1330 severe 919 non-severe infections US & Canada 3.57 odds of severe disease and 4.94 odds of Acute Flaccid Paralysis than controls [61] No
  1. agenotype data not available for meta-analysis