Host factors | Recent history of neutropenia (< 0.5 × 109 neutrophils/L for > 10 days) temporally related to the onset of infection Prolonged use of corticosteroids at a mean minimum dose of 0.3 mg/kg/day of prednisone equivalent for > 3 weeks Treatment with immunosuppressants during the past 90 days Inherited severe immunodeficiency Underlying respiratory diseases including chronic pulmonary diseases (COPD, asthma, lung cancer, bronchiectasis, interstitial lung diseases, and cystic fibrosis) and acute pulmonary diseases (bacterial pneumonia, viral pneumonia, and acute bronchitis) |
Clinical criteria | The presence of 1 of the following 3 signs on chest computed tomography: Dense, well circumscribed lesion(s) with or without a halo sign Air-crescent sign Cavity on chest computed tomography |
Mycological criteria | Cytologic or microscopic evidence of Aspergillus elements or recovery of Aspergillus in sputum or BALF Positive GM test in serum or BALF |