Sputum signatures for invasive pulmonary aspergillosis in patients with underlying respiratory diseases (SPARED): study protocol for a prospective diagnostic trial

Table 1 Studies assessing sputum GM assay for various Aspergillus events

Author	Year	Aspergillus events	Underlying diseases	Sputum type
Kimura [27]	2009	IPA	HD	spontaneous/induced
Fraile [32]	2012	IPA^a	not classified^b	not reported
Delfino [34]	2012	AC	cystic fibrosis	not reported
Baxter [29]	2013	AC	cystic fibrosis	spontaneous
Baxter [28]	2013	ABPA	cystic fibrosis	spontaneous
Chanzá [33]	2014	IPA^a	HD and NHD	not reported
Dhillon [35]	2016	ABPA	cystic fibrosis	not reported

Abbreviations, ABPA allergic bronchopulmonary aspergillosis, AC Aspergillus colonization, HD haematological disease, IPA invasive pulmonary aspergillosis, NHD non-haematological disease
^aEORTC/MSG diagnostic criteria were not used.
^bPatients recruited from Infectious, Pneumology, Oncology Services and Critical Care Unit, without specific underlying diseases classified.

ISSN: 1471-2334