Table 2 Genotype and allele distributions of SNPs between low- and high responders
Gene | SNPs | Genotype /allele | Low responders (N = 41) | High responders (N = 668) | P |
|---|---|---|---|---|---|
TNF | rs1799964 | CC | 1(2.4) | 33(4.9) | 0.766 |
CT | 15(35.3) | 235(35.2) | |||
TT | 25(61.0) | 400(59.9) | |||
C | 17(20.7) | 301(22.5) | 0.705 | ||
T | 65(79.3) | 1035(77.5) | |||
rs1800629 | AA | 0(0.0) | 1(0.1) | 0.440a | |
AG | 5(12.2) | 59(8.8) | |||
GG | 36(87.8) | 608(91.0) | |||
A | 5(6.1) | 61(4.6) | 0.427a | ||
G | 77(93.9) | 1275(95.4) | |||
rs3093671 | AA | 0(0.0) | 1(0.1) | 0.448a | |
AG | 5(12.2) | 60(9.0) | |||
GG | 36(87.8) | 606(90.9) | |||
A | 5(6.1) | 62(4.6) | 0.587a | ||
G | 77(93.9) | 1272(95.4) | |||
rs769177 | CC | 36(87.8) | 608(91.4) | 0.424a | |
CT | 5(12.2) | 56(8.4) | |||
TT | 0(0.0) | 1(0.2) | |||
C | 77(93.9) | 1272(95.6) | 0.408a | ||
T | 5(6.1) | 58(4.4) | |||
rs769178 | GG | 32(78.0) | 519(78.4) | 0.896 | |
GT | 8(19.5) | 133(20.1) | |||
TT | 1(2.4) | 10(1.5) | |||
G | 72(87.8) | 1171(80.9) | 0.145 | ||
T | 10(12.2) | 276(19.1) | |||
MAPK8 | rs17780725 | AA | 5(12.2) | 32(4.8) | 0.083 |
AG | 12(29.3) | 258(38.6) | |||
GG | 24(58.5) | 378(56.6) | |||
A | 22(26.8) | 322(24.1) | 0.576 | ||
G | 60(73.2) | 1014(75.9) | |||
rs3827680 | AA | 8(19.5) | 77(11.7) | 0.213 | |
AG | 15(36.6) | 315(47.9) | |||
GG | 18(43.9) | 266(40.4) | |||
A | 31(37.8) | 469(35.6) | 0.691 | ||
G | 51(62.2) | 847(64.4) |