Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
crude OR [95% CI] | p-value | adjusted OR [95% CI] | p-value | |
Gender (Female vs. Malea) | 0.76 (0.51–1.14) | 0.188 | 0.71 (0.46–1.08) | 0.111 |
Age (per 1 year increase) | 1.00 (0.99–1.01) | 0.672 | 1.00 (0.99–1.01) | 0.850 |
HBV-DNA (per 1 log10 IU/ml increase) | 1.06 (0.97–1.15) | 0.208 | 1.04 (0.94–1.15) | 0.409 |
LAM | 4.03 (1.97–8.25) | < 0.0001 | 4.60 (1.87–11.31) | 0.001 |
ADV | 0.42 (0.27–0.65) | < 0.0001 | 0.53 (0.33–0.86) | 0.009 |
ETV | 0.99 (0.57–1.73) | 0.981 | 2.02 (0.95–4.29) | 0.068 |
TDF | 1.10 (0.52–2.31) | 0.805 | 1.58 (0.67–3.73) | 0.294 |
Geographical origin | ||||
Southa | 1 | 1 | ||
West | 1.01 (0.65–1.58) | 0.951 | 0.75 (0.43–1.32) | 0.323 |
North | 0.58 (0.21–1.58) | 0.287 | 0.49 (0.17–1.41) | 0.184 |
East | 1.79 (1.18–2.71) | 0.006 | 1.22 (0.64–2.33) | 0.552 |
Year of collection | ||||
1997-2002a | 1 | 1 | ||
2003–2005 | 0.58 (0.29–1.17) | 0.128 | 0.88 (0.41–1.92) | 0.754 |
2006–2008 | 0.61 (0.34–1.08) | 0.088 | 1.09 (0.54–2.19) | 0.817 |
2009–2012 | 0.72 (0.41–1.27) | 0.259 | 0.83 (0.36–1.88) | 0.650 |
Genotype (A vs. Da) | 2.15 (1.53–3.02) | < 0.0001 | 2.03 (1.32–3.10) | 0.001 |