Table 2 Factors associated with the presence of at least one immune-associated escape mutation by fitting a uni-multivariable logistic regression model

Gender (Female vs. Male^a)

1.16 (0.76–1.78)

1.20 (0.77–1.87)

Age (per 1 year increase)

1.02 (1.00–1.03)

1.02 (1.00–1.03)

HBV-DNA (per 1 log₁₀ IU/ml increase)

1.03 (0.94–1.14)

1.10 (0.99–1.23)

LAM

1.16 (0.65–2.08)

1.46 (0.71–3.02)

ADV

1.44 (0.96–2.17)

1.31 (0.83–2.06)

ETV^c

1.28 (0.71–2.31)

2.04 (0.97–4.29)

TDF

0.76 (0.31–1.87)

1.13 (0.43–3.02)

 South^a

1

1

 West

0.71 (0.43–1.17)

1.03 (0.55–1.89)

 North

0.55 (0.18–1.62)

0.72 (0.23–2.28)

 East

0.75 (0.46–1.22)

1.26 (0.62–2.55)

 1997-2002^a

1

1

 2003–2005

1.07 (0.42–2.71)

0.79 (0.28–2.20)

 2006–2008

2.37 (1.11–5.07)

1.65 (0.67–4.01)

 2009–2012

1.79 (0.84–3.83)

1.36 (0.50–3.68)

Genotype (D vs. A^a)

2.19 (1.43–3.34)

2.20 (1.32–3.67)