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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe

Fig. 1

The histograms report the percentage of patients with at least one: a immune-associated escape mutation; b NA-induced immune-escape mutation; c stop-codon. The analyses included a total of 828 chronically HBV-infected patients: 573 infected with HBV genotype-D and 255 with HBV genotype-A. Statistically significant differences were assessed by Chi Square Test based on a 2 × 2 contingency table. **: 0.001; ***: P < 0.001. Immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T, sY134L, sC138Y, sC139S, sT140S, sP142S, sD144A/E, sG145A/R, sN146S) were retrieved from literature and known to affect HBsAg recognition by antibodies [2, 13, 14, 39–47]. The NA-induced immune-escape mutations I195M, I196S, and E164D result from drug-resistance mutation M204 V, M204I, and V173 L (Torresi, 2002)

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