Table 1 Characteristics of 138 patients with KP BSI according to CSKP or CRKP isolates

Age (months)

24.8 (1.1–101.6)

10.9 (0.5–98.9)

46.3 (14.1–107.6)

0.021

Male

80 (58.0)

49 (58.3)

31 (57.4)

0.914

Underlying disease

118 (85.5)

67 (79.8)

51 (94.4)

0.032

Hematologic malignancies

66 (55.9)

29 (43.3)

37 (72.5)

0.003

Congenital anomalies

19 (16.1)

15 (22.4)

4 (7.8)

0.043

Prematurity

13 (11.0)

10 (14.9)

3 (5.9)

0.147

Solid tumors

8 (6.8)

6 (9.0)

2 (3.9)

0.463

Malnutrition

7 (5.9)

5 (7.5)

2 (3.9)

0.697

Immunodeficiencies

6 (5.1)

5 (7.5)

1 (2.0)

0.233

 Hematology-oncology

74 (53.6)

35 (41.7)

39 (72.2)

< 0.001

 General medical

32 (23.2)

25 (29.8)

7 (13.0)

0.024

 NICU

14 (10.1)

13 (15.5)

1 (1.9)

0.009

 PICU

6 (4.3)

2 (2.4)

4 (7.4)

0.210

 Surgical

12 (8.7)

9 (10.7)

3 (5.6)

0.366

Healthcare-related infection

114 (82.6)

66 (78.6)

48 (88.9)

0.119

Length of hospitalization

21 (15–32)

21 (15–31.75)

22.5 (12–32.25)

0.825

Length of hospitalization before the onset of BSI

10 (1–15)

8.5 (0–15)

12 (3–15.25)

0.091

Intravascular catheter

108 (78.3)

57 (67.9)

51 (94.4)

< 0.001

Mechanical ventilation

17 (12.3)

7 (8.3)

10 (18.5)

0.076

Fever

122 (88.4)

74 (88.1)

48 (88.9)

0.887

Organ disfunction (any)

53 (38.4)

32 (38.1)

21 (38.9)

0.925

Septic shock

15 (10.9)

6 (7.1)

9 (16.7)

0.079

Leukocytes (cells/mm³)

690 (200–6170)

4180 (300–6790)

295 (120–3887.5)

< 0.001

Neutrophils (cells/mm³)

100 (0–2237.5)

935 (0–2960)

10 (0–367.5)

0.002

< 500 cells/mm³

77 (55.8)

36 (42.9)

41 (75.9)

< 0.001

Empirical antibiotic treatment (n = 138)

< 0.001

 No active antibiotic

56 (40.6)

21 (25.0)

35 (64.8)

–

 ≥ 1 active antibiotic

82 (59.4)

63 (75.0)

19 (35.2)

–

Change in antibiotic treatment after the positive culture

57 (41.3)

29 (34.5)

28 (51.9)

0.044

Definitive antibiotic treatment (n = 134)

< 0.001

 No active antibiotic

29 (21.6)

9 (10.8)

20 (39.2)

–

 ≥ 1 active antibiotic

105 (78.4)

74 (89.1)

31 (60.8)

–

Carbapenem-including treatment(n = 134)

95 (70.9)

59 (71.1)

36 (70.6)

0.951

Length of antibiotic treatment

13 (9–18)

14 (9.25–18)

12 (7–18.25)

0.079

Outcome

 7-day mortality

10 (7.2)

1 (1.2)

9 (16.7)

0.002

 28-day mortality

12 (8.7)

2 (2.4)

10 (18.5)

0.003

 Hospital mortality

17 (12.3)

7 (8.3)

10 (18.5)

0.076