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Table 1 Characteristics of 138 patients with KP BSI according to CSKP or CRKP isolates

From: Risk factors for carbapenem-resistant K. pneumoniae bloodstream infection and predictors of mortality in Chinese paediatric patients

Variable Total (n = 138) CSKP (n = 84) CRKP (n = 54) P
Age (months) 24.8 (1.1–101.6) 10.9 (0.5–98.9) 46.3 (14.1–107.6) 0.021
Male 80 (58.0) 49 (58.3) 31 (57.4) 0.914
Underlying disease 118 (85.5) 67 (79.8) 51 (94.4) 0.032
Hematologic malignancies 66 (55.9) 29 (43.3) 37 (72.5) 0.003
Congenital anomalies 19 (16.1) 15 (22.4) 4 (7.8) 0.043
Prematurity 13 (11.0) 10 (14.9) 3 (5.9) 0.147
Solid tumors 8 (6.8) 6 (9.0) 2 (3.9) 0.463
Malnutrition 7 (5.9) 5 (7.5) 2 (3.9) 0.697
Immunodeficiencies 6 (5.1) 5 (7.5) 1 (2.0) 0.233
Departments
 Hematology-oncology 74 (53.6) 35 (41.7) 39 (72.2) < 0.001
 General medical 32 (23.2) 25 (29.8) 7 (13.0) 0.024
 NICU 14 (10.1) 13 (15.5) 1 (1.9) 0.009
 PICU 6 (4.3) 2 (2.4) 4 (7.4) 0.210
 Surgical 12 (8.7) 9 (10.7) 3 (5.6) 0.366
Healthcare-related infection 114 (82.6) 66 (78.6) 48 (88.9) 0.119
Length of hospitalization 21 (15–32) 21 (15–31.75) 22.5 (12–32.25) 0.825
Length of hospitalization before the onset of BSI 10 (1–15) 8.5 (0–15) 12 (3–15.25) 0.091
Intravascular catheter 108 (78.3) 57 (67.9) 51 (94.4) < 0.001
Mechanical ventilation 17 (12.3) 7 (8.3) 10 (18.5) 0.076
Fever 122 (88.4) 74 (88.1) 48 (88.9) 0.887
Organ disfunction (any) 53 (38.4) 32 (38.1) 21 (38.9) 0.925
Septic shock 15 (10.9) 6 (7.1) 9 (16.7) 0.079
Leukocytes (cells/mm3) 690 (200–6170) 4180 (300–6790) 295 (120–3887.5) < 0.001
Neutrophils (cells/mm3) 100 (0–2237.5) 935 (0–2960) 10 (0–367.5) 0.002
< 500 cells/mm3 77 (55.8) 36 (42.9) 41 (75.9) < 0.001
Empirical antibiotic treatment (n = 138)     < 0.001
 No active antibiotic 56 (40.6) 21 (25.0) 35 (64.8)
 ≥ 1 active antibiotic 82 (59.4) 63 (75.0) 19 (35.2)
Change in antibiotic treatment after the positive culture 57 (41.3) 29 (34.5) 28 (51.9) 0.044
Definitive antibiotic treatment (n = 134)     < 0.001
 No active antibiotic 29 (21.6) 9 (10.8) 20 (39.2)
 ≥ 1 active antibiotic 105 (78.4) 74 (89.1) 31 (60.8)
Carbapenem-including treatment(n = 134) 95 (70.9) 59 (71.1) 36 (70.6) 0.951
Length of antibiotic treatment 13 (9–18) 14 (9.25–18) 12 (7–18.25) 0.079
Outcome     
 7-day mortality 10 (7.2) 1 (1.2) 9 (16.7) 0.002
 28-day mortality 12 (8.7) 2 (2.4) 10 (18.5) 0.003
 Hospital mortality 17 (12.3) 7 (8.3) 10 (18.5) 0.076
  1. Data are n (%) or median (IQR)
  2. P value in bold italic shows that the variables are statistically significant