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Table 3 Genotype and allele distributions of SNPs in the RORC gene in the IFNL3 favorable sub-cohorta

From: Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

RORC SNPs Chronic HCVb (n = 54) Resolved HCVb (n = 67) P-value OR (95% CI)
rs9826
 CC 5 (0.09) 1 (0.01) 0.092  
 TT 26 (0.48) 41 (0.61)
 CT 23 (0.43) 25 (0.37)
 C allele 33 (0.31) 27 (0.20) 0.062 1.74 (0.97–3.19)
 T allele 75 (0.69) 107 (0.80) 0.57 (0.31–1.03)
rs1521177
 GG 6 (0.11) 1 (0.01) 0.040  
 TT 26 (0.48) 43 (0.64)
 GT 22 (0.41) 23 (0.34)
 G allele 34 (0.31) 25 (0.19) 0.021 2.00 (1.11–3.55)
 T allele 74 (0.69) 109 (0.81) 0.50 (0.28–0.90)
  1. aParticipants in the, IFNL3 favorable sub-cohort were screened for, IFNL3 genotypes (rs12979860CC/rs8099917TT/rs12980275AA)
  2. bNumber of cases (frequency)
  3. SNP genotyping was conducted using the iPLEX MassARRAY system (Sequenom Inc., USA), and allele and genotype frequency distributions were calculated. Chi-square (χ2) and Fisher’s exact tests were used to evaluate differences in, SNP frequencies between, HCV carriers and spontaneous resolvers. P-values, odds ratios, (ORs) and 95% confidence intervals, (95% CIs) were determined for association analysis. P-values (two-tailed) < 0.05were considered significant (bold)