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Table 3 Genotype and allele distributions of SNPs in the RORC gene in the IFNL3 favorable sub-cohorta

From: Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

RORC SNPs

Chronic HCVb (n = 54)

Resolved HCVb (n = 67)

P-value

OR (95% CI)

rs9826

 CC

5 (0.09)

1 (0.01)

0.092

 

 TT

26 (0.48)

41 (0.61)

 CT

23 (0.43)

25 (0.37)

 C allele

33 (0.31)

27 (0.20)

0.062

1.74 (0.97–3.19)

 T allele

75 (0.69)

107 (0.80)

0.57 (0.31–1.03)

rs1521177

 GG

6 (0.11)

1 (0.01)

0.040

 

 TT

26 (0.48)

43 (0.64)

 GT

22 (0.41)

23 (0.34)

 G allele

34 (0.31)

25 (0.19)

0.021

2.00 (1.11–3.55)

 T allele

74 (0.69)

109 (0.81)

0.50 (0.28–0.90)

  1. aParticipants in the, IFNL3 favorable sub-cohort were screened for, IFNL3 genotypes (rs12979860CC/rs8099917TT/rs12980275AA)
  2. bNumber of cases (frequency)
  3. SNP genotyping was conducted using the iPLEX MassARRAY system (Sequenom Inc., USA), and allele and genotype frequency distributions were calculated. Chi-square (χ2) and Fisher’s exact tests were used to evaluate differences in, SNP frequencies between, HCV carriers and spontaneous resolvers. P-values, odds ratios, (ORs) and 95% confidence intervals, (95% CIs) were determined for association analysis. P-values (two-tailed) < 0.05were considered significant (bold)