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Table 2 Genotype and allele frequency distributions of IFNL3and RORCSNPs in the primary cohort

From: Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

SNP Genotype Chronic HCVa(n = 64) Resolved HCVa(n = 73) P-value OR (95% CI)
rs12979860 CC 55 (0.85) 70(0.96) 0.105  
  TT 1 (0.02) 0 (0.00)
CT 8 (0.13) 3 (0.04)
C allele 118 (0.92) 143 (0.98) 0.043 0.25 (0.07–0.87)
T allele 10 (0.08) 3 (0.02) 4.04 (1.15–13.89)
rs8099917 TT 58(0.91) 69 (0.95) 0.514  
  GG 0 (0.00) 0 (0.00)
GT 6 (0.09) 4 (0.05)
T allele 122 (0.95) 142 (0.97) 0.523 0.57 (0.16–2.08)
G allele 6 (0.05) 4 (0.03) 1.75 (0.48–6.33)
rs12980275 AA 55 (0.85) 69 (0.96) 0.189  
  GG 1 (0.02) 0 (0.00)
AG 8 (0.13) 4 (0.04)
A allele 118 (0.92) 142 (0.97) 0.096 0.33 (0.10–1.09)
G allele 10 (0.08) 4 (0.03) 3.01 (0.92–9.84)
RORC gene
 rs9826 CC 7 (0.11) 1 (0.01) 0.024  
 (3′ UTR) TT 29 (0.45) 45 (0.62)
  CT 28 (0.44) 27 (0.37)
C allele 42 (0.33) 29 (0.20) 0.015 1.97 (1.14–3.41)
T allele 86 (0.67) 117 (0.80) 0.51 (0.29–0.88)
 rs1521177 GG 6 (0.10) 1 (0.01) 0.017  
 (intron) TT 29 (0.45) 48 (0.66)
  GT 29 (0.45) 24 (0.33)
G allele 41 (0.32) 26 (0.18) 0.006 2.18 (1.24–3.82)
T allele 87 (0.68) 120 (0.82) 0.46 (0.26–0.81)
  1. aNumber of cases (frequency). SNP genotypes were determined using the iPLEX MassARRAY system (Sequenom Inc., USA), and allele frequencies and genotype distributions were calculated. Chi-square (χ2) and Fisher’s exact tests were used to evaluate differences in SNP frequencies between HCV carriers and spontaneous resolvers. P-values, odds ratios, (ORs), and 95% confidence intervals, (95% CIs) were determined for association analysis. P-values (two-tailed) < 0.05 were considered significant (bold)