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Table 2 The 20 most common comorbidities in chronic HCV patients and prevalence of relevant systemic diseases

From: Comorbidities and co-medications in populations with and without chronic hepatitis C virus infection in Japan between 2015 and 2016

  

Chronic HCV patients

(n = 128,967)

Non-HCV patients

(n = 515,868)

Type of comorbidities/relevant systemic diseases

ICD-10 code blocks

n

%

n

%

The 20 most common comorbidities

 Diseases of oesophagus, stomach and duodenum♯

K20-K31

53,817

41.7

94,325

18.3

 Hypertensive diseases♯

I10-I15

40,466

31.4

79,602

15.4

 Metabolic disorders♯

E70-E90

36,403

28.2

71,959

13.9

 Diabetes mellitus♯

E10-E14

33,632

26.1

60,428

11.7

 Other diseases of intestines

K55-K64

31,581

24.5

61,083

11.8

 Episodic and paroxysmal disorders

G40-G47

25,077

19.4

44,756

8.7

 Other dorsopathies

M50-M54

22,629

17.5

39,653

7.7

 Diseases of liver

K70-K77

22,080

17.1

20,432

4.0

 Malignant neoplasms of digestive organs

C15-C26

19,405

15.0

23,518

4.6

 Other forms of heart disease

I30-I52

18,715

14.5

44,546

8.6

 Dermatitis and eczema♯

L20-L30

16,294

12.6

24,107

4.7

 Nutritional anaemias

D50-D53

15,433

12.0

20,678

4.0

 Disorders of gallbladder, biliary tract and pancreas

K80-K87

14,471

11.2

14,977

2.9

 General symptoms and signs

R50-R69

13,548

10.5

22,990

4.5

 Ischaemic heart diseases

I20-I25

12,355

9.6

31,462

6.1

 Chronic lower respiratory diseases

J40-J47

11,400

8.8

23,630

4.6

 Disorders of bone density and structure

M80-M85

10,203

7.9

23,124

4.5

 Other diseases of upper respiratory tract

J30-J39

10,168

7.9

20,404

4.0

 Disorders of ocular muscles, binocular movement, accommodation and refraction

H49-H52

9941

7.7

30,291

5.9

 Cerebrovascular diseases

I60-I69

9914

7.7

28,193

5.5

Relevant systemic diseasesa

 Psychiatric disorders

–b

28,253

21.9

51,813

10.0

 Neoplasms other than liver cancers

–b

26,286

20.4

79,126

15.3

 Cardiovascular diseases

–b

24,000

18.6

62,901

12.2

 Liver cancers

–b

11,878

9.2

1578

0.3

 Renal failure

–b

5180

4.0

9293

1.8

  1. P-values for the comparisons of the percentages in chronic HCV patients and non-HCV patients using the chi-square test were all < 0.0001
  2. aAmong the ten relevant systemic diseases of interest, five diseases that were not defined using ICD-10 three-character code block categories are listed under this heading. The other five diseases are listed in the ranking of the 20 most common comorbidities and indicated by a sharp (♯)
  3. bThese five relevant systemic diseases were defined as follows: psychiatric disorders included mental and behavioural disorders (F00–F99) and sleep disorders (G47). Neoplasms other than liver cancers were defined as C00–D49 except for C22. Cardiovascular diseases included ischaemic heart diseases (I20–I25), heart failure (I50), and cerebrovascular diseases (I60–I69). Liver cancers were defined as C22. Renal failure were defined as N17–N19
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BMC Infectious Diseases

ISSN: 1471-2334

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