Prediction of mortality in severe dengue cases

BMC Infectious Diseases

Table 2 Timing of clinical events in 199 patients hospitalised with severe dengue in 2014

	All (N = 199)		Died (N = 20)		Survived (N = 179)		p-value
	n	n (%) or median (IQR)	n	n (%) or median (IQR)	n	n (%) or median (IQR)	p-value
¹Day of admission	199	4.00 (2.81–5.00)	20	3.51 (2.58–4.38)	179	4.03 (2.93–5.00)	0.29
²Day of development of severe dengue	198	4.63 (3.56–5.67)	20	4.07 (3.22–5.81)	178	4.65 (3.66–5.67)	0.39
³Day of defervescence	194	4.96 (3.92–6.04)	18	4.08 (3.00–5.13)	176	5.02 (4.03–6.13)	0.05
⁴Day of outcome	199	8.75 (7.16–11.0)	20	6.81 (4.91–12.82)	179	8.80 (7.46–10.67)	0.08
Phase at admission, febrile	194	153 (78.8)	18	10 (55.6)	176	143 (81.3)	0.03^a
Phase at severe dengue diagnosis, febrile	193	114 (59.1)	18	6 (33.3)	175	108 (61.7)	0.02
Severe dengue upon presentation	198	73 (36.9)	20	8 (40.0)	178	65 (36.5)	0.76
⁵Day of nadir WBC	199	4.63 (3.75–5.71)	20	3.74 (2.93–5.34)	179	4.71 (3.88–5.73)	0.07
⁶Day of nadir platelet	199	5.50 (4.64–6.50)	20	4.79 (3.40–6.96)	179	5.54 (4.79–6.50)	0.11
⁷Day of lowest serum bicarbonate	197	5.00 (3.92–6.04)	20	5.36 (3.56–8.94)	177	4.92 (3.96–5.92)	0.15
⁸Day of highest serum lactate	190	5.38 (4.13–6.60)	20	5.44 (3.93–9.70)	170	5.35 (4.13–6.50)	0.32
⁹Day of highest serum ALT	198	5.56 (4.42–6.75)	20	5.41 (4.05–7.02)	178	5.58 (4.42–6.75)	0.88
¹⁰Day of highest serum AST	194	5.35 (4.29–6.54)	20	5.26 (4.18–7.39)	174	5.35 (4.38–6.50)	0.81
¹¹Day of highest serum creatinine	199	4.67 (3.67–5.79)	20	4.81 (4.00–8.38)	179	4.67 (3.58–5.71)	0.10

n count of non-missing observations; ^aFisher’s exact test; IQR interquartile range, WBC white blood cell count, AST aspartate transaminase, ALT alanine transaminase; 1–11 These are days from onset of fever

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