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Table 1 Performance evaluation of the CapitalBio™ DNA microarray for rifampin and isoniazid resistance in tuberculosis cases compared with the standard drug sensitivity testing (DST) method for the 671 samples

From: GeneChip analysis of resistant Mycobacterium tuberculosis with previously treated tuberculosis in Changchun

CapitalBio™ DNA microarray Conventional drug susceptibility testing        
No.susceptible (%) No.resistant (%) Total No. Sensitivity (%) Specificity (%) AR PPV (%) NPV (%) Kappa
Rifampin     83.1 98.7 93.9 96.6 92.9 0.85
 Susceptible 458 (98.7) 35 (16.9) 493       
 Resistant 6(1.3) 172 (83.1) 178       
 Total 464 207 671       
Isoniazid     79.9 99.6 93.1 98.8 91.1 0.84
 Susceptible 450 (99.3) 44 (20.5) 494       
 Resistant 2 (0.7) 175 (79.5) 177       
 Total 452 219 671       
  1. Abbreviations: PPV positive predictive value, NPV negative predictive value, AR agreement rate