Fig. 4

Kinetics of ALT level in 4 different groups of patients according to the stage of liver disease (i.e. with/without cirrhosis) and therapy outcome (i.e. fail or SVR12). a Box-plot describe the distribution of the 3179 patients according values of ALT level patients either before the start of therapy (blue boxes; T0) and eventually 12 weeks after therapy (red boxes; FUP12). Almost all patients had ALT value above upper normal limit (black dotted line; 40 U/L) before therapy. More than 75% of patients who achieve SVR12 normalized ALT at 12 weeks after the end of therapy. A normalization of ALT values was also reported in about 50% of those who did not achieve SVR at 12 weeks after the end of therapy. b Temporal variation of ALT levels before treatment and 12 weeks after the endo of therapy. Estimates, 95%CI and p-values were carried out according to a mixed effect model which take in account correlation of data at the level of each individual patients. A significant reduction of ALT is reported for all patients. However average reduction of ALT levels is about 2 time higher in those who achieved SVR12 than in those who did not