Table 2 Predictors of mortality in the identified studies, if any
From: High mortality in patients with Mycobacterium avium complex lung disease: a systematic review
Data set | Negative association with all-cause mortality | Positive association with all-cause mortality | Reference |
|---|---|---|---|
1 | Surgical treatment | Yeager 1973 [12] | |
2 | Male sex Age ≥ 70 years Presence of systemic and/or respiratory comorbidity FC disease BMI < 18.5 kg/m2 Anaemia Hypoalbuminemia Erythrocyte sedimentation rate ≥ 50 mm/h | Hayashi 2012 [13] | |
3 | High Charlson comorbidity index Presence of FC lesions Malignancy | Ito 2012 [14] | |
4 | NB disease | FC disease FC + NB disease Usual interstitial pneumonia Emphysema Other lung disease | Yamakawa 2013 [15] |
5 | Prior tuberculosis Bronchiectasis Asthma | Male sex Older age Chronic obstructive pulmonary disease Interstitial lung disease Lung cancer HIV infection Cystic fibrosis Bone marrow transplant | Morimoto 2014 [16] |
6 | Chronic pulmonary aspergillosis Cavitation Emphysema | Zoumot 2014 [17] | |
7 | Male sex Age ≥ 70 years BMI < 18.5 kg/m2 Absence of bloody sputum hypoalbuminaemia Erythrocyte sedimentation rate > 40 mm/h | Gochi 2015 [18] | |
8,9 | Male sex Age ≥ 70 years Malignancy, including lung cancer BMI < 18.5 kg/m2 Lymphocyte count < 1000/μl FC disease | Kumagai 2017 [19]a | |
10 | Male sex Age ≥ 65 years High comorbidity level Positive smear | Andréjak 2010 [20] | |
11 | NTM-PD with multiple species of NTM isolated | Male sex Increasing age Comorbid conditions | Marras 2017 [21] |
12 | Older age Low BMI Pneumonectomy Remnant cavitary lesions following pulmonary resection | Asakura 2017 [22]a | |
13,14 | Lung cancer | Novosad 2017 [23]a | |
15 | Increasing age Male sex Involvement of > 1 lung zone Low initial body weight | Research Committee of the British Thoracic Society 2002 [24] | |
16,17 | Adding clarithromycin vs. ciprofloxacin to rifampicin and ethambutol therapy regimen | Jenkins 2008 [25] |