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Table 2 Predictors of mortality in the identified studies, if any

From: High mortality in patients with Mycobacterium avium complex lung disease: a systematic review

Data set Negative association with all-cause mortality Positive association with all-cause mortality Reference
1 Surgical treatment   Yeager 1973 [12]
2   Male sex
Age ≥ 70 years
Presence of systemic and/or respiratory comorbidity
FC disease
BMI < 18.5 kg/m2
Erythrocyte sedimentation rate ≥ 50 mm/h
Hayashi 2012 [13]
3   High Charlson comorbidity index
Presence of FC lesions
Ito 2012 [14]
4 NB disease FC disease
FC + NB disease
Usual interstitial pneumonia
Other lung disease
Yamakawa 2013 [15]
5 Prior tuberculosis Bronchiectasis Asthma Male sex
Older age
Chronic obstructive pulmonary disease
Interstitial lung disease
Lung cancer
HIV infection
Cystic fibrosis
Bone marrow transplant
Morimoto 2014 [16]
6   Chronic pulmonary aspergillosis
Zoumot 2014 [17]
7   Male sex
Age ≥ 70 years
BMI < 18.5 kg/m2
Absence of bloody sputum hypoalbuminaemia
Erythrocyte sedimentation rate > 40 mm/h
Gochi 2015 [18]
8,9   Male sex
Age ≥ 70 years
Malignancy, including lung cancer
BMI < 18.5 kg/m2
Lymphocyte count < 1000/μl
FC disease
Kumagai 2017 [19]a
10   Male sex
Age ≥ 65 years
High comorbidity level
Positive smear
Andréjak 2010 [20]
11 NTM-PD with multiple species of NTM isolated Male sex
Increasing age
Comorbid conditions
Marras 2017 [21]
12   Older age
Remnant cavitary lesions following pulmonary resection
Asakura 2017 [22]a
13,14   Lung cancer Novosad 2017 [23]a
15   Increasing age
Male sex
Involvement of > 1 lung zone
Low initial body weight
Research Committee of the British Thoracic Society 2002 [24]
16,17 Adding clarithromycin vs. ciprofloxacin to rifampicin and ethambutol therapy regimen   Jenkins 2008 [25]
  1. BMI body mass index, FC fibrocavitary disease, HIV human immunodeficiency virus, NB nodular bronchiectatic disease, NTM nontuberculous mycobacteria, NTM-PD nontuberculous mycobacterial pulmonary disease
  2. aFactors found to be significant by multivariate analysis are listed