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Fig. 4 | BMC Infectious Diseases

Fig. 4

From: Live attenuated Salmonella typhimurium vaccines delivering SaEsxA and SaEsxB via type III secretion system confer protection against Staphylococcus aureus infection

Fig. 4

Evaluation of cellular immune response against rSaEsxA and rSaEsxB by ELISPOT. Mice were immunized with PBS, N106, N19, and N20 strains (n = 3–4/group). Eight or nine days after the second booster, splenocytes were prepared and incubated with specific antigens for 20 h. IFN-γ-producing cells with stimulator rSaEsxA (a) and rSaEsxB (c) were detected by IFN-γ ELISPOT assay. And for IL-17A-producing cells stimulated with rSaEsxA (b) and rSaEsxB (d), IL-17A ELISPOT assays were conducted. SFC, Spot-Forming Cells. Results of one of two experiments are shown. For statistical analysis, student’s t test was used. Data were represented as means ± SEM

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