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Table 2 Review of cases report of tigecycline-induced acute pancreatitis --- Clinical findings of cases

From: Tigecycline-induced acute pancreatitis in a renal transplant patient: a case report and literature review

Author Onset of symptoms Clinical manifestation Amylase/Lipase levels (u/L) CRP (mg/l) CT scan AP severity Time to symptoms relieved (days) Time to recovery of enzymes (days)
Glison M 13 days, abdominal pain Acute abdominal ‘stab-like’ pain (−)/1000 35 Pancreatic oedema without any necrotic flows (Balthazar Stage 1). Mild 2 43
Lipshitz J 14 days, epigastric pain Nausea, vomiting, abdominal pain 806/1406 NA Mild inflammatory stranding about the duodenum and minimal fluid in the left retroperitoneum. Mild 3 5
Marshall RS 3 days, uncontrolled emesis Nausea, vomiting, fever and loss of appetite 180/156 NA Acute pancreatitis Mild 2 7
Hung WY 3 days, nausea and vomiting Persistent and worsening nausea and vomiting, abdominal pain 926/749 NA NA NA 3 5
Prot-Labarthe S 14 days, abdominal pain Abdominal pain, recurrent vomiting (−)/603 NA Inflammation involving pancreas and peripancreatic fat without necrosis (Ranson Score 2 and Balthazar stage 2). Mild 3 5
Otero RS 7 days Nausea, vomiting, epigastric pain, distention 255/424 NA Pancreatic enlargement, low density shadow of pancreas tail (grade D on Balthazar score) Mild 3 12
Mascarello M 12 days Nausea, vomiting and acute severe upper abdominal pain 312/382 131 Inflammation of the pancreas and peripancreatic fat, necrosis of 40% of the pancreatic gland, peripancreatic stranding, and fluid collection (Balthazar CT severity index 7). severe ≤10 ≤10
Hemphill MT 10 days Abdominal pain NA/732 NA Acute pancreatitis Mild 6 6
Hemphill MT 3 days Mild nausea, epigastric tenderness 381/268 NA Acute pancreatitis Mild 5 5
Marot JC 6 days, epigastric pain Nausea, epigastric pain 750/936 NA An oedematous pancreatitis (grade D on Balthazar score) Mild 4 18
Marot JC 7 days, abdominal pain on day 8 Nausea, vomiting and loss of appetite 552/1660 NA Acute pancreatitis, no necrosis visible without contrast injection (grade D on Balthazar score) Mild 5 4
Davido B 6 days, Anorexia, vomiting and abdominal discomfort NA/ 2460 NA Typical oedematous infiltrate (Balthazar A). Mild 2 2
Davido B 20 days Nausea, abdominal discomfort NA/ 1340 NA NA NA 1 1
  1. CT Computerized Tomography, AP Acute Pancreatitis, CRP C-Reactive Protein