Table 1 Baseline characteristics of 2,025,730 cohort members according to their PCV13 vaccination status before the study started

 50-64 years

1,393 (27.8)

1,015,783 (50.3)

<0.001

 65-79 years

2,256 (45.0)

687,149 (34.0)

 ≥ 80 years

1,361 (27.2)

317,788 (15.7)

Sex, male

2,750 (54.9)

929,322 (46.0)

<0.001

History of pneumococcal disease in previous 2 yrs.

91 (1.8)

2,634 (0.1)

<0.001

History of all cause pneumonia in previous 2 yrs.

324 (6.5)

14,432 (0.7)

<0.001

PPV23 vaccination at any time

4,050 (80.8)

782,896 (38.7)

<0.001

Influenza vaccination in the prior autumn

4,143 (82.7)

679,345 (33.6)

<0.001

Chronic respiratory disease

1,605 (32.0)

209,916 (10.4)

<0.001

Chronic heart disease

1,553 (31.0)

245,929 (12.2)

<0.001

Diabetes mellitus

1,574 (31.4)

338,749 (16.8)

<0.001

Chronic liver disease

341 (6.8)

41,173 (2.0)

<0.001

Chronic renal disease

454 (9.1)

16,302 (0.8)

<0.001

Alcoholism

162 (3.2)

58,313 (2.9)

0.142

Smoking

465 (9.3)

315,613 (15.6)

<0.001

Immunocompromise^c

2,109 (42.1)

173,945 (8.6)

<0.001

 Immunocompetent subjects

920 (18.4)

220,718 (10.9)

<0.001

 Immunocompromised subjects

1,696 (33.9)

106,667 (5.3)

<0.001