Table 4 Data for hospitalization and risk factors, by type of discharge (N = 115)
From: Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital
Discharge (N = 56) | In-hospital mortality (N = 59) | OR (95% CI) | P value | |
|---|---|---|---|---|
Gender | ||||
Female | 23 (41.1) | 21 (35.6) | 1.00 | |
Male | 33 (58.9) | 38 (64.4) | 1.26 (0.59; 2.69) | 0.546 |
Age (years) | 1.03 (1.01; 1.05) | 0.015 | ||
Mean (SD) | 63.80 (19.33) | 72.03 (15.53) | ||
Median [1st Q - 3rd Q] | 65.00 [50–81.50] | 76.00 [60–85] | ||
Length of stay (days) | 1.00 (1.00; 1.00) | 0.952 | ||
Mean (SD) | 69.02 (140.67) | 70.58 (137.32) | ||
Median [1st Q - 3rd Q] | 32 [20.25–64.25] | 36 [23.50–56] | ||
Time to start empiric therapy with antifungal after blood culture | ||||
Within 24 h | 23 (41.1) | 28 (47.5) | 1.00 | |
More than 24 h | 27 (48.2) | 21 (35.6) | 0.64 (0.29; 1.41) | 0.268 |
No use of antifungal drug | 6 (10.7) | 10 (16.9) | 1.37 (0.44; 4.56) | 0.593 |
Used antimicrobial | ||||
No | 1 (1.8) | 1 (1.7) | 1.00 | |
Yes | 55 (98.2) | 58 (98.3) | - 11-22-2016 17:19:0 s2 | 0.970 |
Used chemotherapy | ||||
No | 52 (92.9) | 51 (86.4) | 1.00 | |
Yes | 4 (7.1) | 8 (13.6) | 2.04 (0.60; 8.03) | 0.268 |
Used corticosteroid | ||||
No | 15 (26.8) | 5 (8.5) | 1.00 | |
Yes | 41 (73.2) | 54 (91.5) | 3.95 (1.40; 12.96) | 0.014 |
Used parenteral nutrition | ||||
No | 37 (66.1) | 32 (54.2) | 1.00 | |
Yes | 19 (33.9) | 27 (45.8) | 1.64 (0.78; 3.53) | 0.197 |
Used some type of central venous catheter | ||||
No | 22 (39.3) | 7 (11.9) | 1.00 | |
Yes | 34 (60.7) | 52 (88.1) | 4.81 (1.93; 13.30) | 0.001 |
Had any type of surgery | ||||
No | 20 (35.7) | 16 (27.1) | 1.00 | |
Yes | 36 (64.3) | 43 (72.9) | 1.49 (0.68; 3.33) | 0.322 |
Stayed at the intensive care unit | ||||
No | 17 (30.4) | 4 (6.8) | 1.00 | |
Yes | 39 (69.6) | 55 (93.2) | 5.99 (2.04; 22.07) | 0.003 |
Length of stay in the intensive care unit (days) (n = 94) | 1.04 (1.02; 1.06) | 0.001 | ||
Mean (SD) | 16.03 (16.86) | 28.42 (25.86) | ||
Median [1st Q - 3rd Q] | 10.00 (5.00–17.50) | 23.00 (7.50–36.00) | ||
Neutropenia | ||||
No | 54 (96.4) | 55 (93.2) | 1.00 | |
Yes | 2 (3.6) | 4 (6.8) | 1.96 (0.37; 14.59) | 0.447 |
Used vasoactive drug | ||||
No | 23 (41.1) | 6 (10.2) | 1.00 | |
Yes | 33 (58.9) | 53 (89.8) | 6.16 (2.39; 18.12) | < 0.001 |
Used mechanical ventilation | ||||
No | 26 (46.4) | 7 (11.9) | 1.00 | |
Yes | 30 (53.6) | 52 (88.1) | 6.44 (2.61; 17.74) | < 0.001 |
Hemodialysis | ||||
No | 45 (80.4) | 32 (54.2) | 1.00 | |
Yes | 11 (19.6) | 27 (45.8) | 3.45 (1.53; 8.21) | 0.004 |
Blood transfusion | ||||
No | 48 (85.7) | 40 (67.8) | 1.00 | |
Yes | 8 (14.3) | 19 (32.2) | 2.85 (1.16; 7.55) | 0.027 |
Positive blood culture even when using antifungal therapy | ||||
No | 44 (78.6) | 36 (61.0) | 1.00 | |
Yes | 12 (21.4) | 23 (39.0) | 2.34 (1.04; 5.48) | 0.043 |