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Table 4 Diagnostic criteria for RS3PE syndrome [9]

From: RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report

Satisfies all of the following 4 items:  
・Bilateral pitting edema of both hands and/or feet (rarely unilateral hand/ ft involvement)  
・Sudden onset of polyarthritis  
・Age > 50 years (occasional reports in young people)  
・Persistent rheumatoid factor seronegativity