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Table 5 Relationship between mutations detected and relative expression levels of agr locus

From: Sub-inhibitory concentrations of oxacillin modify the expression of agr locus in Staphylococcus aureus clinical strains belonging to different clonal complexes

    RNAIII   agrA  
Mutations Strains CC a Absence vs Presence b
Means±SD
P c Absence vs Presence
Means±SD
P
42Val > Gly SA_123; SA_520; SA_170015; SA_190006; SA_70002 45; 8 8.11 ± 14.27 vs. 40.22 ± 51.37 0.001 0.76 ± 0.53 vs. 5.26 ± 3.46 0.000
251Tyr > Phe SA_123; SA_520; SA_170015 45 19.58 ± 39.28 vs. 16.90 ± 9.73 0.597 1.92 ± 3.16 vs. 3.51 ± 1.22 0.035
417Glu > Lys SA_123 45 19.88 ± 36.58 vs. 8.66 ± 3.83 0.422 2.03 ± 2.96 vs. 4.57 ± 1.04 0.019
103I > T SA_170015 45 18.49 ± 36.39 vs. 27.16 ± 8.56 0.563 2.21 ± 3.03 vs. 2.94 ± 0.74 0.556
138Lys/del-1 bp) SA_180015 8 20.56 ± 36.30 vs. 0.22 ± 0.05 0.000 2.40 ± 2.99 vs. 0.26 ± 0.89 0.000
262Asp > Ala SA_190006; SA_70002 8 10.17 ± 13.81 vs. 74.29 ± 67.51 0.005 1.42 ± 1.40 vs. 8.27 ± 4.01 0.000
258Phe > Ile SA_190006; SA_70002 8 10.17 ± 13.81 vs. 74.29 ± 67.51 0.005 1.42 ± 1.40 vs. 8.27 ± 4.01 0.000
138Phe/del-1 bp) SA_80004 5 20.80 ± 36.44 vs. 0.14 ± 0.04 0.000 2.41 ± 2.41 vs. 0.16 ± 0.85 0.000
96Ser > Leu SA_103 5 20.47 ± 36.35 vs.1.29 ± 0.56 0.000 2.42 ± 3.02 vs 0.56 ± 0.27 0.000
121I > T SA_170006 5 20.53 ± 36.31 vs. 0.51 ± 0.24 0.000 2.42 ± 3.00 vs 0.36 ± 0.75 0.000
136Lys > Arg SA_10009; SA_10014 15 17.91 ± 37.60 vs. 25.01 ± 19.04 0.478 2.49 ± 3.16 vs 1.08 ± 0.32 0.000
55Gly > Arg SA_80001; SA_107 30 20.86 ± 37.41 vs. 6.59 ± 6.82 0.002 2.40 ± 3.12 vs 1.33 ± 0.52 0.007
  1. a Clonal Complex
  2. b Values of expression are showed as relative means ± standard deviation (SD) according to the presence and absence of mutation detected relative to the agr group reference strains
  3. c Bold numbers indicate statistical significant results (P < 0.05)