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Table 3 Predictors of all-cause mortality

From: Mortality and treatment response amongst HIV-infected patients 50 years and older accessing antiretroviral services in South Africa

Variable at ART initiation

Original analyses

Sensitivity analysesa

 

Univariate

Multivariate

Univariate

Multivariate

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Group

  < 50 years

1.0

 

1.0

 

1.0

 

1.0

 

  ≥ 50 years

1.29 (0.91–1.85)

0.157

1.60 (1.08–2.39)

0.019

0.98 (0.75–1.29)

0.908

1.07 (0.79–1.44)

0.652

Gender

 Male

1.0

 

1.0

 

1.0

 

1.0

 

 Female

1.42 (1.16–1.73)

<.001

1.14 (0.91–1.44)

0.242

1.41 (1.23–1.61)

<.001

1.31 (1.12–1.53)

<.001

Site

 Urban

1.0

 

1.0

 

1.0

 

1.0

 

 Rural

1.24 (1.01–1.53)

0.043

1.20 (0.94–1.53)

0.147

1.53(1.32–1.78)

<.001

1.49 (1.25–1.78)

<.001

CD4+ count

(per 50 cells/mm3 increase)

0.73 (0.67–0.78)

<.001

0.78 (0.72–0.84)

<.001

0.90 (0.86–0.94)

<.001

0.93 (0.89–0.98)

0.003

Body mass index (per 5 kg/m2 increase)

0.66 (0.58–0.74)

<.001

0.76 (0.66–0.87)

<.001

0.77(0.71–0.83)

<.001

0.84 (0.77–0.91)

<.001

WHO stage

 Stage 1

1.0

 

1.0

 

1.0

 

1.0

 

 Stage 2

1.50 (0.94–2.40)

0.091

1.49 (0.89–2.48)

0.129

0.83 (0.65–1.06)

0.14

0.84 (0.64–1.10)

0.212

 Stage 3

2.47(1.65–3.71)

<.001

2.12 (1.34–3.36)

0.001

1.15 (0.94–1.40)

0.181

1.18 (0.93–1.49)

0.172

 Stage 4

5.01 (3.23–7.75)

<.001

4.18 (2.51–6.95)

<.001

1.62 (1.26–2.07)

<.001

1.72 (1.28–2.32)

<.001

Presented with diabetes

 No

1.0

 

1.0

 

1.0

 

1.0

 

 Yes

1.55 (0.69–3.48)

0.286

2.67 (1.16–6.14)

0.021

1.08 (0.56–2.08)

0.821

1.83 (0.94–3.60)

0.077

Presented with hypertension

 No

1.0

 

1.0

 

1.0

 

1.0

 

 Yes

0.50 (0.24–1.05)

0.067

0.57 (0.26–1.24)

0.158

0.51 (0.31–0.84)

0.008

0.58 (0.34–1.00)

0.049

Past history of TB

 Yes

1.23 (1.00–1.52)

0.051

0.89 (0.70–1.12)

0.323

1.03 (0.89–1.19)

0.732

0.91 (0.78–1.08)

0.291

 No

1.0

 

1.0

 

1.0

 

1.0

 

Prevalent TB

 Yes

1.0

 

1.0

 

1.0

 

1.0

 

 No

1.24 (0.98–1.64)

0.068

1.82 (1.34–2.45)

<.001

1.23 (1.03–1.46)

0.020

1.41 (1.15–1.75)

0.001

  1. aAssuming all patients who were loss to follow-up died