Variable at ART initiation | Original analyses | Sensitivity analysesa | ||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Group | ||||||||
< 50 years | 1.0 | 1.0 | 1.0 | 1.0 | ||||
≥ 50 years | 1.29 (0.91–1.85) | 0.157 | 1.60 (1.08–2.39) | 0.019 | 0.98 (0.75–1.29) | 0.908 | 1.07 (0.79–1.44) | 0.652 |
Gender | ||||||||
Male | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Female | 1.42 (1.16–1.73) | <.001 | 1.14 (0.91–1.44) | 0.242 | 1.41 (1.23–1.61) | <.001 | 1.31 (1.12–1.53) | <.001 |
Site | ||||||||
Urban | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Rural | 1.24 (1.01–1.53) | 0.043 | 1.20 (0.94–1.53) | 0.147 | 1.53(1.32–1.78) | <.001 | 1.49 (1.25–1.78) | <.001 |
CD4+ count (per 50 cells/mm3 increase) | 0.73 (0.67–0.78) | <.001 | 0.78 (0.72–0.84) | <.001 | 0.90 (0.86–0.94) | <.001 | 0.93 (0.89–0.98) | 0.003 |
Body mass index (per 5 kg/m2 increase) | 0.66 (0.58–0.74) | <.001 | 0.76 (0.66–0.87) | <.001 | 0.77(0.71–0.83) | <.001 | 0.84 (0.77–0.91) | <.001 |
WHO stage | ||||||||
Stage 1 | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Stage 2 | 1.50 (0.94–2.40) | 0.091 | 1.49 (0.89–2.48) | 0.129 | 0.83 (0.65–1.06) | 0.14 | 0.84 (0.64–1.10) | 0.212 |
Stage 3 | 2.47(1.65–3.71) | <.001 | 2.12 (1.34–3.36) | 0.001 | 1.15 (0.94–1.40) | 0.181 | 1.18 (0.93–1.49) | 0.172 |
Stage 4 | 5.01 (3.23–7.75) | <.001 | 4.18 (2.51–6.95) | <.001 | 1.62 (1.26–2.07) | <.001 | 1.72 (1.28–2.32) | <.001 |
Presented with diabetes | ||||||||
No | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Yes | 1.55 (0.69–3.48) | 0.286 | 2.67 (1.16–6.14) | 0.021 | 1.08 (0.56–2.08) | 0.821 | 1.83 (0.94–3.60) | 0.077 |
Presented with hypertension | ||||||||
No | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Yes | 0.50 (0.24–1.05) | 0.067 | 0.57 (0.26–1.24) | 0.158 | 0.51 (0.31–0.84) | 0.008 | 0.58 (0.34–1.00) | 0.049 |
Past history of TB | ||||||||
Yes | 1.23 (1.00–1.52) | 0.051 | 0.89 (0.70–1.12) | 0.323 | 1.03 (0.89–1.19) | 0.732 | 0.91 (0.78–1.08) | 0.291 |
No | 1.0 | 1.0 | 1.0 | 1.0 | ||||
Prevalent TB | ||||||||
Yes | 1.0 | 1.0 | 1.0 | 1.0 | ||||
No | 1.24 (0.98–1.64) | 0.068 | 1.82 (1.34–2.45) | <.001 | 1.23 (1.03–1.46) | 0.020 | 1.41 (1.15–1.75) | 0.001 |