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Table 3 Predictors of all-cause mortality

From: Mortality and treatment response amongst HIV-infected patients 50 years and older accessing antiretroviral services in South Africa

Variable at ART initiation Original analyses Sensitivity analysesa
  Univariate Multivariate Univariate Multivariate
HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Group
  < 50 years 1.0   1.0   1.0   1.0  
  ≥ 50 years 1.29 (0.91–1.85) 0.157 1.60 (1.08–2.39) 0.019 0.98 (0.75–1.29) 0.908 1.07 (0.79–1.44) 0.652
Gender
 Male 1.0   1.0   1.0   1.0  
 Female 1.42 (1.16–1.73) <.001 1.14 (0.91–1.44) 0.242 1.41 (1.23–1.61) <.001 1.31 (1.12–1.53) <.001
Site
 Urban 1.0   1.0   1.0   1.0  
 Rural 1.24 (1.01–1.53) 0.043 1.20 (0.94–1.53) 0.147 1.53(1.32–1.78) <.001 1.49 (1.25–1.78) <.001
CD4+ count
(per 50 cells/mm3 increase)
0.73 (0.67–0.78) <.001 0.78 (0.72–0.84) <.001 0.90 (0.86–0.94) <.001 0.93 (0.89–0.98) 0.003
Body mass index (per 5 kg/m2 increase) 0.66 (0.58–0.74) <.001 0.76 (0.66–0.87) <.001 0.77(0.71–0.83) <.001 0.84 (0.77–0.91) <.001
WHO stage
 Stage 1 1.0   1.0   1.0   1.0  
 Stage 2 1.50 (0.94–2.40) 0.091 1.49 (0.89–2.48) 0.129 0.83 (0.65–1.06) 0.14 0.84 (0.64–1.10) 0.212
 Stage 3 2.47(1.65–3.71) <.001 2.12 (1.34–3.36) 0.001 1.15 (0.94–1.40) 0.181 1.18 (0.93–1.49) 0.172
 Stage 4 5.01 (3.23–7.75) <.001 4.18 (2.51–6.95) <.001 1.62 (1.26–2.07) <.001 1.72 (1.28–2.32) <.001
Presented with diabetes
 No 1.0   1.0   1.0   1.0  
 Yes 1.55 (0.69–3.48) 0.286 2.67 (1.16–6.14) 0.021 1.08 (0.56–2.08) 0.821 1.83 (0.94–3.60) 0.077
Presented with hypertension
 No 1.0   1.0   1.0   1.0  
 Yes 0.50 (0.24–1.05) 0.067 0.57 (0.26–1.24) 0.158 0.51 (0.31–0.84) 0.008 0.58 (0.34–1.00) 0.049
Past history of TB
 Yes 1.23 (1.00–1.52) 0.051 0.89 (0.70–1.12) 0.323 1.03 (0.89–1.19) 0.732 0.91 (0.78–1.08) 0.291
 No 1.0   1.0   1.0   1.0  
Prevalent TB
 Yes 1.0   1.0   1.0   1.0  
 No 1.24 (0.98–1.64) 0.068 1.82 (1.34–2.45) <.001 1.23 (1.03–1.46) 0.020 1.41 (1.15–1.75) 0.001
  1. aAssuming all patients who were loss to follow-up died