Fig. 4

Alignment of antigenic residues of capsid protein (P2 region) in strains circulating in Brazil, 2011-2014. Antigenic residues are divided in five epitopes (A-E). The prototype strains representative of the epidemic strain variants that emerged between 2009 and 2012 are highlighted in blue. Amino acid residues that differ from those of the prototype are highlighted in yellow and green. a Structure modeling of the VP1 protein (PDB 4OP7) showing the amino acid replacement in NoV GII.4 New Orleans_2009 lineages from Manaus, Brazil. Antigenic epitopes are colored in yellow (A), blue (B), green (C), red (D), and purple (E). b Structure modeling of the VP1 protein (PDB 4OP7) showing the amino acid replacement in NoV GII.4 Sydney_2012 lineages from Manaus, Brazil