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Table 1 Characteristics, CSF and serum measures in CSF RPR+ and CSF RPR- patients

From: The performance of rapid plasma reagin (RPR) titer in HIV-negative general paresis after neurosyphilis therapy

Characteristic

All Patients (n = 105)

CSF RPR+ Patients (n = 62)

CSF RPR- Patients (n = 43)

P a

Male sex

91/105(87%)

54/62(87%)

37/43(86%)

0.876

Age, median years (IQR)

52 (47–58)

53(47–58)

52 (47–56)

0.432

MMSE (IQR)

14(12–17)

14(12–17)

14(11–17)

0.982

CSF WBC count

  > 5 cells/μl

26/89(29%)

14/46(30%)b

12/43(28%)

0.793

 Median cells/ml (IQR)

3(1–6)

3(0.75–6)

2(1–6)

0.878

CSF protein concentration

  > 45 mg/dl

73/89(82%)

34/46(74%)b

39/43(91%)

0.039

 Median mg/dl (IQR)

62(48–75)

62.5(45–75.25)

61(50–75)

0.577

Reactive CSF RPR

62/105 (59%)

62/62(100%)

0/43(0%)

 

 Median CSF RPR titer (IQR)

1:2 (1:2–1:4)

 

Serum RPR titer

  ≥ 1: 32

21/108(19%)

19/62(31%)

2/43(4.7%)

0.001

 1: 16

16/108(15%)

8/62(13%)

8/43(18.6%)

0.424

 1: 1–1: 8

68/108(63%)

35/62(56%)

33/43(76.7%)

0.032

 Median serum RPR titer (IQR)

1:8(1:4–1:16)

1:8(1:4–1:32)

1:4(1:4–1:8)

< 0.001

 Normalized by final follow-up visit

14/27(52%)

6/13(46%)c

8/14(57%)d

0.568

  1. Data are no. (%) of patients, unless otherwise indicated. IQR interquartile range, RPR rapid plasma regain, MMSE mini-mental state examination
  2. aAssociations between categorical variables were assessed using the ×2 test or Fisher’s exact test. Associations between continuous variables and categorical variables were assessed using the Mann-Whitney U test
  3. bData are for 46 patients
  4. cData are for 13 patients
  5. dData are for 14 patients