TY - JOUR AU - Chen, Lu AU - Wang, Yan AU - Zhang, Tao AU - Li, Ying AU - Meng, Ti AU - Liu, Leichao AU - Hao, Ruifang AU - Dong, Yalin PY - 2018 DA - 2018/04/02 TI - Utility of posaconazole therapeutic drug monitoring and assessment of plasma concentration threshold for effective prophylaxis of invasive fungal infections: a meta-analysis with trial sequential analysis JO - BMC Infectious Diseases SP - 155 VL - 18 IS - 1 AB - Posaconazole therapeutic drug monitoring (TDM) is increasingly used in clinical practice. However, the utility of posaconazole TDM and the target of posaconazole plasma concentration for clinical successful prophylaxis remain uncertain and controversial. The aim of this study was to evaluate posaconazole exposure-response relationship and determine an optimum posaconazole concentration for prophylaxis against invasive fungal infections (IFIs). SN - 1471-2334 UR - https://doi.org/10.1186/s12879-018-3055-3 DO - 10.1186/s12879-018-3055-3 ID - Chen2018 ER -