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Table 4 Characteristics of the group of patients discharged alive and its association with 5 year mortality

From: Risk factors for long-term mortality in patients admitted with severe infection

Variable Total
(n = 876)
Dead at 5 years
(n = 243)
Crude OR (95% CI) p value Adjusted OR (95% CI)
Age, median ± SD, years 63 ± 20 73 ± 14 1.04 (1.03–1.05), per year < 0.001 1.03, per year (1.02–1.05)
Female, n (%) 458 (52) 132 (54) 0.89 (0.66–1.20) 0.454  
Underlying conditions, n (%)
 Diabetes mellitus 183 (21) 70 (29) 1.86 (1.32–2.63) < 0.001 1.65 (1.06–2.56)
 Atherosclerosis 283 (21) 74 (31) 2.11 (1.50–2.96) < 0.001  
 Immunosuppression 195 (22) 51 (21) 0.90 (0.63–1.29) 0.575  
  Chemotherapy 26 (3) 17 (7)    
  Radiotherapy 6 (1) 4 (2)    
  Long-term corticoid 166 (18) 34 (14)    
  Short-term corticoid 16 (2) 5 (2)    
  HIV positive (non-AIDS) 6 (1) 1 (0)    
  AIDS 2 (0) 1 (0)    
 Chronic liver disease 14 (2) 6 (3) 1.98 (0.68–5.76) 0.211  
 Chronic heart failure 62 (7) 33 (14) 3.27 (1.94–5.52) < 0.001  
 Chronic respiratory disease 66 (7) 43 (11,4) 4.17 (2.39–7.26) < 0.001 2.27 (1.09–4.69)
 Chronic kidney disease 138 (16) 46 (19) 1.37 (0.93–2.03) 0.111  
 End Stage kidney disease 66 (8) 20 (8) 1.14 (0.66–1.98) 0.639  
 Cancer 27 (3) 18 (7) 5.55 (2.46–12.53) < 0.001 4.69 (1.71–12.83)
 Haematologic cancer 42 (5) 18 (7) 2.03 (1.08–3.81) 0.028  
No comorbidities 322 (37) 48 (20) 0.32 (0.23–0.46) < 0.001  
Karnofsky Index < 70 230 (26) 115 (47) 4.05 (2.93–5.59) < 0.001 2.50 (1.63–3.83)
Type of infection     < 0.001  
 Community 436 (50) 97 (40) 1.0   
 Healthcare associated 187 (21) 75 (31) 2.34 (1.62–3.39)   
 Hospital-acquired 253 (29) 71 (29) 1.36 (0.96–1.95)   
Severity of infection     0.61  
 Infection 255 (29) 66 (27) 1.0   
 Sepsis 325 (37) 96 (40) 1.20 (0.83–1.73)   
 Severe sepsis 246 (28) 70 (29) 1.14 (0.77–1.67)   
 Septic shock 50 (6) 11 (5) 0.80 (0.39–1.67)   
SAPS II score, per point 27 ± 10 31 ± 9 1.05 (1.03–1.06) < 0.001  
SOFA score, per point 2 ± 2 2 ± 2 0.99 (0.93–1.06) 0.771  
Focus of infection     0.005  
 Respiratory 345 (39) 94 (39) 1.0   
 Urinary 304 (35) 100 (41) 1.31 (0.94–1.83)   
 Abdominal 280 (21) 33 (14) 0.60 (0.38–0.94)   
 Other 47 (5) 16 (7) 1.38 (0.72–2.64)   
Microbiologic documentation 593 (68) 179 (74) 1.48 (1.07–2.06) 0.020  
Positive blood cultures 126 (14) 46 (19) 1.61 (1.09–2.40) 0.018 1.66 (1.04–2.64)
Infection by a MDR pathogen 265 (49) 89 (53) 1.24 (0.86–1.79) 0.245  
Infection by an ESKAPE pathogen 82 (15) 30 (18) 1.33 (0.81–2.17) 0.256  
Inappropriate antibiotherapy 113 (19) 43 (24) 1.55 (1.01–2.39) 0.044  
  1. CI Confidence interval, SD Standard deviation, HIV Human immunodeficiency virus, AIDS Acquired immunodeficiency syndrome, OR Odds ratio