Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar

BMC Infectious Diseases

Table 2 Frequency of G6PD deficiency and G6PD variants in Myanmar malaria patients

	Amino acid substitution	WHO classification^a	Female	Male	Total (%)
Normal			30	172	202 (80.1)
G6PD deficiency			7	43	50 (19.9)
Vanua Lava (383T>C)	L128P	II	0	0	0 (0.0)
Mahidol (487G>A)	G163S	III	3	31	34 (13.5)
Mediterranean (563C>T)	S188F	II	1	1	2 (0.8)
Coimbra (592C>T)	R198C	II	0	0	0 (0.0)
Viangchan (871G>A)	V291M	III	0	3	3 (1.2)
Union (1360C>T)	R454C	II	0	1	1 (0.4)
Canton (1376G>T)	R459L	III	1	0	1 (0.4)
Kaiping (1388G>A)	R463H	II	2	7	9 (3.6)

^aClass I, severe deficiency (<10% activity) with chronic (nonspherocytic) hemolytic anemia; class II, severe deficiency (<10% activity) with intermittent hemolysis severe deficiency; class III, mild deficiency (10-60% activity) hemolysis with stressors only; class IV, non-deficient, variant, no clinical sequelae (50-150% activity); Class V: Increased enzyme activity, no clinical sequelae (150>% activity)

ISSN: 1471-2334