Skip to main content

Table 6 Agreement between three rapid tests and MGIT for detection of MDR-TB

From: Cost analysis of rapid diagnostics for drug-resistant tuberculosis

   Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
LR+
(95% CI)
LR-
(95% CI)
% Agreement
(95% CI)
MDR LPA (n = 656) 0.99 (0.97, 0.99) 1.00 (0.97, 1.00) 1.00 (0.99, 1.00) 0.97 (0.94, 0.99) 217 (31, 1534) 0.01 (0.01, 0.03) 0.99 (0.98, 1.00)
MODS (n = 674) 1.00 (0.98, 1.00) 1.00 (0.97, 1.00) 1.00 (0.99, 1.00) 0.99 (0.96, 1.00) 216 (31, 1527) 0.00 (0.00, 0.02) 1.00 (0.99, 1.00)
PSQ (n = 538) 0.99 (0.97, 0.99) 0.99 (0.95, 1.00) 1.00 (0.98, 1.00) 0.96 (0.91, 0.98) 135 (19, 951) 0.02 (0.01, 0.03) 0.99 (0.97, 0.99)
  1. CI Confidence Interval, LPA Line-probe assay, LR- Negative Likelihood Ratio, LR+ Positive Likelihood Ratio, MDR-TB Multi-Drug Resistant Tuberculosis, MGIT Mycobacteria Growth Indicator Tube, MODS Microscopic-observation drug-susceptibility assay, NPV Negative Predictive Value, PPV Positive Predictive Value, PSQ Pyrosequencing