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Table 6 Agreement between three rapid tests and MGIT for detection of MDR-TB

From: Cost analysis of rapid diagnostics for drug-resistant tuberculosis

  

Sensitivity

(95% CI)

Specificity

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

LR+

(95% CI)

LR-

(95% CI)

% Agreement

(95% CI)

MDR

LPA (n = 656)

0.99 (0.97, 0.99)

1.00 (0.97, 1.00)

1.00 (0.99, 1.00)

0.97 (0.94, 0.99)

217 (31, 1534)

0.01 (0.01, 0.03)

0.99 (0.98, 1.00)

MODS (n = 674)

1.00 (0.98, 1.00)

1.00 (0.97, 1.00)

1.00 (0.99, 1.00)

0.99 (0.96, 1.00)

216 (31, 1527)

0.00 (0.00, 0.02)

1.00 (0.99, 1.00)

PSQ (n = 538)

0.99 (0.97, 0.99)

0.99 (0.95, 1.00)

1.00 (0.98, 1.00)

0.96 (0.91, 0.98)

135 (19, 951)

0.02 (0.01, 0.03)

0.99 (0.97, 0.99)

  1. CI Confidence Interval, LPA Line-probe assay, LR- Negative Likelihood Ratio, LR+ Positive Likelihood Ratio, MDR-TB Multi-Drug Resistant Tuberculosis, MGIT Mycobacteria Growth Indicator Tube, MODS Microscopic-observation drug-susceptibility assay, NPV Negative Predictive Value, PPV Positive Predictive Value, PSQ Pyrosequencing