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Table 5 Agreement between three rapid tests and MGIT for detection of XDR-TB

From: Cost analysis of rapid diagnostics for drug-resistant tuberculosis

  Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI) LR+ (95% CI) LR- (95% CI) % Agreement (95% CI)
XDR LPA (n = 656) 0.49 (0.36, 0.61) 1.00 (0.99, 1.00) 1.00 (0.87, 1.00) 0.94 (0.92, 0.96) 0.51 (0.41, 0.65) 0.95 (0.93, 0.96)
MODS (n = 674) 0.83 (0.72, 0.91) 1.00 (0.99, 1.00) 0.97 (0.88, 0.99) 0.98 (0.97, 0.99) 251 (63, 1003) 0.17 (0.10, 0.28) 0.98 (0.96, 0.99)
PSQ (n = 538) 0.69 (0.56, 0.79) 1.00 (0.98, 1.00) 0.96 (0.85, 0.99) 0.96 (0.93, 0.97) 162 (40, 651) 0.32 (0.22, 0.45) 0.96 (0.94, 0.97)
  1. CI Confidence Interval, LPA Line-probe assay, LR- Negative Likelihood Ratio, LR+ Positive Likelihood Ratio, MGIT Mycobacteria Growth Indicator Tube, MODS Microscopic-observation drug-susceptibility assay, NPV Negative Predictive Value, PPV Positive Predictive Value, PSQ Pyrosequencing, XDR-TB Extremely-Drug Resistant Tuberculosis