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Table 5 Agreement between three rapid tests and MGIT for detection of XDR-TB

From: Cost analysis of rapid diagnostics for drug-resistant tuberculosis

 

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

LR+ (95% CI)

LR- (95% CI)

% Agreement (95% CI)

XDR

LPA (n = 656)

0.49 (0.36, 0.61)

1.00 (0.99, 1.00)

1.00 (0.87, 1.00)

0.94 (0.92, 0.96)

–

0.51 (0.41, 0.65)

0.95 (0.93, 0.96)

MODS (n = 674)

0.83 (0.72, 0.91)

1.00 (0.99, 1.00)

0.97 (0.88, 0.99)

0.98 (0.97, 0.99)

251 (63, 1003)

0.17 (0.10, 0.28)

0.98 (0.96, 0.99)

PSQ (n = 538)

0.69 (0.56, 0.79)

1.00 (0.98, 1.00)

0.96 (0.85, 0.99)

0.96 (0.93, 0.97)

162 (40, 651)

0.32 (0.22, 0.45)

0.96 (0.94, 0.97)

  1. CI Confidence Interval, LPA Line-probe assay, LR- Negative Likelihood Ratio, LR+ Positive Likelihood Ratio, MGIT Mycobacteria Growth Indicator Tube, MODS Microscopic-observation drug-susceptibility assay, NPV Negative Predictive Value, PPV Positive Predictive Value, PSQ Pyrosequencing, XDR-TB Extremely-Drug Resistant Tuberculosis