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Table 1 Final multivariable logistic regression model of risk factors for treatment failure at 30 days in patients with SAB

From: Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia

Variable Univariate analysis Multivariable logistic regression
p-value Odds ratio 95% CI p-value
Age > 70 years <0.001 4.13 1.54-11.07 0.005
Albumin (g/L) <0.001 0.88 0.80-0.96 0.003
CRP > 250 mg/L 0.002 5.41 1.93-15.19 0.001
Persistent fevers 0.029 6.65 1.73-25.62 0.006
Healthcare attendance 0.003 0.13 0.03-0.59 0.008
Pitt bacteraemia score ≥ 2a 0.04 2.94 1.03-8.39 0.044
Echocardiogram performed 0.092 0.23 0.06-0.94 0.041
Appropriate empiric treatment 0.018 0.14 0.02-0.85 0.032
DNR orderb <0.001    -
WCC (x 109/L) 0.048    -
ICU admission 0.003    -
APACHE II score > 11.5b 0.003    -
Combination treatment > 7 days 0.026    -
Severe sepsis 0.029    -
Body mass index (kg/m2) 0.037    -
Directed vancomycin treatment 0.044    -
Dementia 0.055    -
Directed flucloxacillin treatment 0.058    -
Nephrotoxicity 0.068    -
ARF at onset of SAB 0.07    -
Residence in LTCFb 0.09    -
Female sex 0.091    -
MRSA 0.098    -
  1. aScore derived by CART analysis was > 1.5; as calculation of the score requires whole numbers, this is assumed to signify a Pitt bacteraemia score of ≥ 2
  2. bRemoved from multivariable model due to collinearity
  3. CRP C-reactive protein, DNR do not resuscitate order, WCC white cell count, ICU intensive care unit, ARF acute renal failure, SAB staphylococcus aureus bacteraemia, LTCF long-term care facility, MRSA methicillin-resistant S. aureus, CART classification and regression tree, CI confidence interval