Table 3 Frequency of mutations associated with SLDs resistance in MDR MTB isolates
ATB drug | Gene | Position | Substitution | Amino acid change | Number of isolates | Sub-total | Total |
|---|---|---|---|---|---|---|---|
FQs | gyrA | Codon 90 | GCG → GTG | Ala / Val | 2 | 19 | 21 |
GCG → ACG | Ala / Thr | 2 | |||||
Codon 91 | TCG → CCG | Ser / Pro | 3 | ||||
Codon 94 | GAC → GCC | Asp / Ala | 10 | ||||
GAC → AAC | Asp / Asn | 1 | |||||
GAC → CAC | Asp / His | 1 | |||||
gyrB | – | – | – | 0 | 0 | ||
Aminoglycosides /cyclic peptides | rrs | – | – | – | 0 | 0 | |
tlyA | – | – | – | 0 | |||
eis | Position 12 | C → T | – | 1 | 2 | ||
Position 14 | C → T | – | 1 |