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Table 8 Receiver operator characterization of TMKmt Ag and host specific IgG EIA-ODs for detecting TB exposure and or disease status among HIV positive individuals

From: Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection

Among HIV positive individuals Active TB vs OD values classification
% (95% CI)
  ATB vs No TB ATB vs (LTBI & No TB)
TMKmt Ag Capture
 n 128 220
 Prevalence 80.0 (73.0,86.9) 63.0 (56.0,69.1)
 Sensitivity 99.0 (94.7,100.0) 73.9 (65.8,81.0)
 Specificity 68.0 (46.5,85.1) 90.2 (81.7,95.7)
 PPV 92.7 (86.2,96.8) 92.7 (86.2,96.8)
 NPV 94.4 (72.7,99.9) 67.3 (57.7,75.9)
 ROC area 83.5 (74.1,92.9) 82.1 (77.2,87.0)
TMKmt Ab Capture
 n 154 167
 Prevalence 74.0 (68.0, 81.9) 72.0 (65.0,79.1)
 Sensitivity 96.6 (91.4, 99.1) 92.6 (86.3,96.5)
 Specificity 21.1 (9.5, 37.3) 34.8 (21.4,50.2)
 PPV 78.9 (71.2,85.3) 78.9 (71.2,85.3)
 NPV 66.7 (34.9,90.1) 64.0 (42.5,82.0)
 ROC 58.8 (52.0,65.6) 63.7 (56.3,71.0)