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Table 3 Predictors for ARTI-attributable hospital admission among all immunocompromised patients and stratified by age-groups (adults vs children)

From: Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

N = 215 (152 adults, 63 children)a

Univariable analyses

Multivariable analyses

OR (95% CI)

OR (95% CI)

P value

Increasing age (by 10Y range)

All

1.0 (0.9;1.1)

1.0 (0.9;1.2)

0.558

Adults

1.6 (1.3;2.1)

1.4 (1.0;1.8)

0.027

Children

0.6 (0.2;1.8)

Bacterial co-infection

All

1.6 (0.8;3.4)

1.5 (0.7;3.3)

0.340

Adults

2.2 (0.9;5.2)

1.7 (0.6;4.5)

0.286

Children

0.8 (0.2;3.3)

1.0 (0.2;4.6)

0.995

ALC

All

1.0 (1.0;1.2)

1.0 (1.0;1.2)

0.420

Adults

1.0 (1.0;1.2)

1.0 (1.0;1.2)

0.436

Children

0.8 (0.5;1.2)

0.8 (0.5;1.2)

0.309

SOT

All

2.1 (0.9;5.1)

1.9 (0.8;4.6)

0.166

Adults

2.1 (0.9;5.4)

1.6 (0.6;4.4)

0.312

Children

1.7 (0.1;53.3)

Leukemia/lymphoma

All

4.0 (1.7;9.5)

3.9 (1.7;9.7)

0.002

Adults

3.0 (1.0;9.3)

1.5 (0.4;5.2)

0.556

Children

7.5(1.1;149.7)

Solid tumor

All

7.2 (2.6;21.2)

7.4 (2.7;21.9)

< 0.001

Adults

7.4 (2.1;28.4)

5.2 (1.4;20.9)

0.015

Children

10.5 (1.2;240.1)

Chronic immunosuppressive medication

All

10.5 (3.7;32.9)

9.5 (3.3;30.2)

< 0.001

Adults

8.2 (2.6;28.4)

4.1 (1.1;16.0)

0.034

Children

35.0 (2.6;1450.5)

PID

All

4.3 (0.7–26.1)

4.5 (0.7;29.0)

0.097

Children

10.5 (0.8–298.2)

  1. Absolute lymphocyte counts (ALC), Hematopoietic stem cell recipients (HSCT), Primary immunodeficiency disease (PID) Solid organ transplant (SOT), Acute-respiratory-tract infection (ARTI)
  2. aN refers to the total number of patients included in all multivariable analyses for whom information on all predictors and outcomes were available. 24 patients (23 adults – 1 child) were excluded from univariable and multivariable analyses because of missing values for nALC
  3. Limited sample size in the pediatric subset limited the number of predictors, which could be included in multivariable analyses (−)